Venture Capital Firms in the USA

Early-stage firm investing in digital health and data/security infrastructure, including healthcare IT and enterprise SaaS.

• Healthcare
• Other
• Security

• Seed, Series A
• $750K – $6.0M
• Boston, MA
• 97 portfolio companies

Operator-led enterprise fund investing in technical B2B software, including security and infrastructure products. Helpful for founders needing enterprise GTM and scaling support.

• Enterprise
• Security
• Developer Tools

• Seed, Series A
• $500K – $3.0M
• San Francisco, CA
• 13 portfolio companies

Investing in early-stage Blockchain startups innovating in DeFi, tokenization, and core infrastructure.

• Other

• Pre-Seed, Seed
• $500K – $2.5M
• San Francisco, CA
• 1 portfolio company

14W invests in category-leading global brands, especially focusing on consumer and B2B solutions disrupting legacy systems.

• SaaS
• Healthcare
• Enterprise

• Seed
• $1.0M – $5.0M
• New York, NY
• 3 portfolio companies

Focused on advancing dual-use capabilities in hardware and software for defense and intelligence applications.

• Other
• Security
• Deep Tech

• Pre-Seed, Seed
• $500K – $3.0M
• Chicago, IL
• 1 portfolio company

1M1B Ventures invests in startups solving societal challenges using AI for Governance and impact-driven technology solutions in underserved regions.

• Other

• seed+
• $250K – $5.0M
• San Francisco, CA & Bengaluru, India
• 2 portfolio companies

Early-stage fund investing in frontier/AI and enterprise software, often at pre-seed with conviction checks.

• AI / ML
• SaaS
• Developer Tools

• Pre-Seed, Seed
• $250K – $1.5M
• San Francisco, CA
• 23 portfolio companies

Focuses on founders building marketplaces with B2B applications that enhance microtransaction systems or improve digital collaboration workflows.

• Marketplace

• Seed
• $300K – $1.5M
• Seattle, WA, USA
• 2 portfolio companies

Early-stage investment fund focused exclusively on blockchain, Web3, and crypto startups reshaping financial systems.

• Other

• Pre-Seed, Seed
• $250K – $1.5M
• San Francisco, CA
• 2 portfolio companies

Investing in scalable hardware-enabled SaaS technologies for smart industrial systems and enterprise security applications.

• SaaS
• Deep Tech
• Other

• Seed, Series A
• $500K – $3.0M
• Denver, CO
• 1 portfolio company

Pre-seed/seed fund focused on being an early check for software companies across sectors.

• Other
• SaaS
• Enterprise

• Pre-Seed, Seed
• $250K – $1.0M
• Alexandria, VA
• 26 portfolio companies

Invests in early-stage AI-driven startups focused on transforming traditional industries like real estate, construction, and logistics.

• Other
• AI / ML

• Pre-Seed, Seed
• $500K – $2.0M
• Boulder, CO
• 1 portfolio company

2XN Ventures backs disruptive SaaS startups leveraging AI for business efficiency and workflow transformation.

• SaaS
• AI / ML
• Other

• Pre-Seed, Seed
• $250K – $1.0M
• New York, NY
• 33 portfolio companies

318 Capital invests in early-stage B2B, SaaS, and enterprise software ventures with advanced AI or workflow automation applications.

• SaaS
• Enterprise
• AI / ML

• Pre-Seed, Seed
• $250K – $2.0M
• New York, NY
• 4 portfolio companies

Backs cutting-edge companies transforming the workplace using AI and SaaS solutions targeted at HR and training.

• Other
• SaaS
• AI / ML

• Seed
• $500K – $3.5M
• Boston, MA
• 200 portfolio companies

Focuses on fintech infrastructure with an emphasis on blockchain-based systems for lending and payments.

• Fintech
• Other

• Pre-Seed
• $50K – $300K
• San Francisco, CA
• 1 portfolio company

Targets transformative startups in the industrial, construction, and IoT sectors.

• SaaS
• Deep Tech
• Other

• Seed, Series A
• $1.0M – $5.0M
• Stamford, CT
• 2 portfolio companies

Focuses on early-stage B2B software startups that drive operational efficiency and productivity through advanced automation.

• SaaS
• Other
• Enterprise

• Pre-Seed, Seed
• $250K – $2.5M
• New York, NY
• 2 portfolio companies

Africa-focused VC investing in global-tech companies with strong Africa footprint, heavily including fintech.

• Other
• Fintech
• Marketplace

• Seed, Series A
• $500K – $3.0M
• New York, NY
• 12 portfolio companies

Invests in companies solving major world problems; education and economic opportunity can fit where outcomes are measurable.

• Other
• EdTech
• Healthcare

• Seed
• $250K – $2.0M
• San Francisco, CA

Focuses on startups building deep tech solutions to tackle the world's biggest problems, including sustainability, climate change, and urban innovation.

• Other
• Deep Tech

• Seed, seed+
• $1.0M – $4.0M
• San Francisco, CA
• 4 portfolio companies

Global early-stage investor and accelerator platform investing at pre-seed/seed across software categories.

• Other
• SaaS
• Enterprise

• Pre-Seed, Seed
• $100K – $2.0M
• San Francisco, CA
• 5 portfolio companies

511 Ventures focuses on AI-enabled enterprise infrastructure and tools aimed at safety, stability, and optimization within high-consequence B2B verticals.

• Other
• Deep Tech
• SaaS

• Seed, Series A
• $250K – $2.5M
• Boston, MA
• 1 portfolio company

Focuses on Web3 applications enabling community building and empowering creators through decentralized platforms.

• Other
• Fintech
• Developer Tools

• Seed, Series A
• $500K – $3.0M
• New York, NY
• 59 portfolio companies