Venture Capital Firms in the USA

Focused exclusively on high-growth companies in healthcare and financial technology.

• Healthcare
• Other

• Series A, Series B
• $5.0M – $30.0M
• Greenwich, CT
• 16 portfolio companies

Venture collaborative that invests early and helps startups build commercial relationships with corporates.

• Enterprise
• Other
• Security

• Pre-Seed, Seed
• $250K – $1.0M
• Chicago, IL
• 2 portfolio companies

Pre-seed fund/accelerator investing in very early startups, with emphasis on underrepresented founders.

• Other
• Healthcare
• Enterprise

• Pre-Seed
• $25K – $250K
• New York, NY
• 31 portfolio companies

Early-stage firm investing in digital health and data/security infrastructure, including healthcare IT and enterprise SaaS.

• Healthcare
• Other
• Security

• Seed, Series A
• $750K – $6.0M
• Boston, MA
• 88 portfolio companies

Operator-led enterprise fund investing in technical B2B software, including security and infrastructure products. Helpful for founders needing enterprise GTM and scaling support.

• Enterprise
• Security
• Developer Tools

• Seed, Series A
• $500K – $3.0M
• San Francisco, CA
• 8 portfolio companies

Investing in early-stage Blockchain startups innovating in DeFi, tokenization, and core infrastructure.

• Other

• Pre-Seed, Seed
• $500K – $2.5M
• San Francisco, CA
• 1 portfolio company

Focused on early-stage investments in dual-use technologies with applications for defense and federal government agencies.

• Other
• Security

• Pre-Seed, Seed
• $1.0M – $3.0M
• Austin, TX
• 2 portfolio companies

Invests in product-first founders building early-stage SaaS solutions and e-commerce platforms with scalable infrastructure.

• Other
• SaaS

• Pre-Seed, Seed
• $100K – $500K
• Palo Alto, California
• 1 portfolio company

Seed-stage software investor backing ambitious B2B and AI companies. Relevant when the product is framed as a category-defining system for a workflow-heavy vertical.

• SaaS
• AI / ML
• Other

• Seed
• $500K – $1.0M
• San Francisco, CA
• 24 portfolio companies

11.2 Capital is an early-stage investor with a strong fintech and software orientation. It can fit infrastructure products that improve financial workflows and transaction reliability.

• Fintech
• Other
• Developer Tools

• Pre-Seed, Seed
• $250K – $1.0M
• New York, New York
• 46 portfolio companies

14W invests in category-leading global brands, especially focusing on consumer and B2B solutions disrupting legacy systems.

• SaaS
• Healthcare
• Enterprise

• Seed
• $1.0M – $5.0M
• New York, NY
• 2 portfolio companies

1776 Ventures is a seed-stage firm focused on startups addressing critical societal needs, which can include education-related infrastructure and services. It is a regional specialist-style investor w...

• EdTech
• Other
• Fintech

• Seed
• Washington, District of Columbia
• 2 portfolio companies

1855 Capital is a seed and early-stage fund tied to Penn State University and often backs startups connected to the university ecosystem. It can be useful for education-adjacent or university-enabled ...

• EdTech
• Other

• Seed
• State College, Pennsylvania

Focused on advancing dual-use capabilities in hardware and software for defense and intelligence applications.

• Other
• Security
• Deep Tech

• Pre-Seed, Seed
• $500K – $3.0M
• Chicago, IL
• 1 portfolio company

1M1B Ventures invests in startups solving societal challenges using AI for Governance and impact-driven technology solutions in underserved regions.

• Other

• seed+
• $250K – $5.0M
• San Francisco, CA & Bengaluru, India
• 2 portfolio companies

Early-stage fund investing in frontier/AI and enterprise software, often at pre-seed with conviction checks.

• AI / ML
• SaaS
• Developer Tools

• Pre-Seed, Seed
• $250K – $1.5M
• San Francisco, CA
• 23 portfolio companies

Invests in early-stage game studios and platforms redefining the gaming industry, particularly multiplayer and UGC experiences with cutting-edge AI capabilities.

• Other
• AI / ML

• Seed, Pre-Seed
• $250K – $5.0M
• Los Angeles, CA
• 1 portfolio company

Focuses on founders building marketplaces with B2B applications that enhance microtransaction systems or improve digital collaboration workflows.

• Marketplace

• Seed
• $300K – $1.5M
• Seattle, WA, USA
• 2 portfolio companies

Early-stage investment fund focused exclusively on blockchain, Web3, and crypto startups reshaping financial systems.

• Other

• Pre-Seed, Seed
• $250K – $1.5M
• San Francisco, CA
• 2 portfolio companies

Investing in scalable hardware-enabled SaaS technologies for smart industrial systems and enterprise security applications.

• SaaS
• Deep Tech
• Other

• Seed, Series A
• $500K – $3.0M
• Denver, CO
• 1 portfolio company

Pre-seed/seed fund focused on being an early check for software companies across sectors.

• Other
• SaaS
• Enterprise

• Pre-Seed, Seed
• $250K – $1.0M
• Alexandria, VA
• 26 portfolio companies

Invests in early-stage AI-driven startups focused on transforming traditional industries like real estate, construction, and logistics.

• Other
• AI / ML

• Pre-Seed, Seed
• $500K – $2.0M
• Boulder, CO
• 1 portfolio company

232 Ventures is an early-stage software investor with a broad B2B focus and an interest in scalable SaaS and AI. It is a plausible fit for workflow software serving SMB merchants and operational teams...

• SaaS
• AI / ML
• Other

• Pre-Seed, Seed
• Chicago, Illinois

2XN Ventures backs disruptive SaaS startups leveraging AI for business efficiency and workflow transformation.

• SaaS
• AI / ML
• Other

• Pre-Seed, Seed
• $250K – $1.0M
• New York, NY
• 33 portfolio companies