Venture Capital Firms in San Francisco

Browse 1,280 venture capital firms headquartered in San Francisco. Median check across the 1253 firms that disclose a range is $500K–$2.5M; most active at Seed, Pre-Seed, Series A; concentrated in SaaS, AI / ML, Enterprise. Every firm is verified — explore their thesis, check size, and portfolio, then get matched with the best-fit investors for your startup.

Verified San Francisco VC firms

01 Advisors

Operator-led enterprise fund investing in technical B2B software, including security and infrastructure products. Helpful for founders needing enterprise GTM and scaling support.

  • Enterprise
  • Security
  • Developer Tools
  • Seed, Series A
  • $500K – $3.0M
  • San Francisco, CA
  • 8 portfolio companies

0xVentures

Investing in early-stage Blockchain startups innovating in DeFi, tokenization, and core infrastructure.

  • Other
  • Pre-Seed, Seed
  • $500K – $2.5M
  • San Francisco, CA
  • 1 portfolio company

10VC

Seed-stage software investor backing ambitious B2B and AI companies. Relevant when the product is framed as a category-defining system for a workflow-heavy vertical.

  • SaaS
  • AI / ML
  • Other
  • Seed
  • $500K – $1.0M
  • San Francisco, CA
  • 24 portfolio companies

1M1B Ventures

1M1B Ventures invests in startups solving societal challenges using AI for Governance and impact-driven technology solutions in underserved regions.

  • Other
  • seed+
  • $250K – $5.0M
  • San Francisco, CA & Bengaluru, India
  • 2 portfolio companies

1Sharpe Ventures

Early-stage fund investing in frontier/AI and enterprise software, often at pre-seed with conviction checks.

  • AI / ML
  • SaaS
  • Developer Tools
  • Pre-Seed, Seed
  • $250K – $1.5M
  • San Francisco, CA
  • 23 portfolio companies

1confirmation

Early-stage investment fund focused exclusively on blockchain, Web3, and crypto startups reshaping financial systems.

  • Other
  • Pre-Seed, Seed
  • $250K – $1.5M
  • San Francisco, CA
  • 2 portfolio companies

3rd Rail Capital

Focuses on fintech infrastructure with an emphasis on blockchain-based systems for lending and payments.

  • Fintech
  • Other
  • Pre-Seed
  • $50K – $300K
  • San Francisco, CA
  • 1 portfolio company

42 Ventures

42 Ventures seeks to invest in media and entertainment startups that have a clear path to captivating global audiences.

  • Other
  • Seed
  • $250K – $3.0M
  • San Francisco, CA

50 Years (impact; education possible)

Invests in companies solving major world problems; education and economic opportunity can fit where outcomes are measurable.

  • Other
  • EdTech
  • Healthcare
  • Seed
  • $250K – $2.0M
  • San Francisco, CA

50 Years VC

Focuses on startups building deep tech solutions to tackle the world's biggest problems, including sustainability, climate change, and urban innovation.

  • Other
  • Deep Tech
  • Seed, seed+
  • $1.0M – $4.0M
  • San Francisco, CA
  • 4 portfolio companies

500 Global

Global early-stage investor and accelerator platform investing at pre-seed/seed across software categories.

  • Other
  • SaaS
  • Enterprise
  • Pre-Seed, Seed
  • $100K – $2.0M
  • San Francisco, CA
  • 5 portfolio companies

5050 VC

Early-stage fund backing diverse founding teams across software and general technology.

  • Other
  • SaaS
  • Enterprise
  • Pre-Seed, Seed
  • $50K – $500K
  • San Francisco, CA
  • 37 portfolio companies

50x Ventures

Targeting seed stage investments in scalable clean energy technology.

  • Climate / Energy
  • Other
  • Seed
  • $500K – $2.5M
  • San Francisco, CA

ACME Capital

ACME backs early-stage deep-tech founders who pair technical ambition with decisive execution.

  • SaaS
  • AI / ML
  • Other
  • Seed, Series A
  • $1.0M – $3.0M
  • San Francisco, California, United States
  • 8 portfolio companies

Abstract Ventures

Early-stage fund investing in ambitious founders across consumer and enterprise software.

  • Other
  • Pre-Seed, Seed
  • $250K – $1.0M
  • San Francisco, CA
  • 5 portfolio companies

Acceleprise Ventures

Primarily invests in early-stage B2B SaaS companies with an accelerator model.

  • SaaS
  • Pre-Seed, Seed
  • $500K – $1.5M
  • San Francisco, CA
  • 68 portfolio companies

Accelera Capital

Accelera Capital is dedicated to advancing customer service through AI-driven automation tools, specifically aimed at SMBs.

  • Other
  • Pre-Seed
  • San Francisco, CA

Accelerator Ventures

Invests very early in technology companies, often at pre-seed/seed, with a long-running focus on helping founders get to product-market fit.

  • SaaS
  • Other
  • Marketplace
  • Pre-Seed, Seed
  • $250K – $1.5M
  • San Francisco, CA
  • 28 portfolio companies

Accessibility Ventures

Accessibility Ventures focuses solely on investing in assistive technology and startups improving the lives of people with disabilities globally.

  • Other
  • EdTech
  • Healthcare
  • Pre-Seed, Seed
  • $500K – $3.0M
  • San Francisco, CA
  • 18 portfolio companies

Actual Ventures

Focuses on early-stage consumer-facing companies shaping how people engage with media and culture.

  • Other
  • Consumer
  • Pre-Seed, Seed
  • $500K – $2.0M
  • San Francisco, CA
  • 1 portfolio company

Acuity Ventures

Acuity Ventures focuses exclusively on early-stage startups building compliance, audit, and accounting innovation, particularly AI-driven tools for regulated industries.

  • Other
  • SaaS
  • Seed
  • $750K – $5.0M
  • San Francisco, CA
  • 2 portfolio companies

Acústica Ventures

Focused on companies using acoustic technologies to innovate within biotech and medical device sectors.

  • Healthcare
  • Other
  • Pre-Seed
  • $75K – $250K
  • San Francisco, CA
  • 1 portfolio company

a]ventures

Early-stage fund for technical founders building developer infrastructure.

  • Developer Tools
  • AI / ML
  • Pre-Seed, Seed
  • $100K – $1.0M
  • US-SF

a_capital

A.Capital invests in technology companies across enterprise, consumer, and crypto, with recent portfolio investments including AI-focused businesses. It says it sizes investments to company needs and ...

  • AI / ML
  • Enterprise
  • Developer Tools
  • Seed, Early Growth, Deployment-ready Architecture
  • $1.0M – $3.0M
  • San Francisco, United States
  • 9 portfolio companies

Showing 1–24 of 1280 firms — page 1 of 54.

Most active San Francisco VC firms in the last 12 months

Ranked by investments dated 2025–2026 in our portfolio data.

  1. Right Side Capital Management — 14 investments
  2. Kindred Ventures — 12 investments
  3. Crypto Nexus Capital — 10 investments
  4. Forerunner Ventures — 7 investments
  5. Striker VC — 5 investments
  6. AdTech Catalyst — 3 investments
  7. Builders VC — 3 investments
  8. Galileo Ventures — 3 investments

Frequently Asked Questions

How many VC firms are based in San Francisco?
Investor Match tracks 1,280 verified venture capital firms headquartered in San Francisco.
What is a typical check size for VC firms in San Francisco?
Across the 1253 firms in San Francisco that disclose a range, the median check runs $500K–$2.5M. Individual firms vary widely — check each profile for its own range.
What stages do San Francisco VC firms invest at?
The most common stage focuses among San Francisco firms we track are Seed (968), Pre-Seed (797), Series A (172). Firms often invest across more than one stage.
Which sectors do San Francisco investors back most?
The sectors most represented among San Francisco firms we track are SaaS (583), AI / ML (438), Enterprise (275).
How do I get introduced to investors in San Francisco?
Upload your pitch deck to Investor Match and we'll match you with investors in San Francisco that fit your startup, then help you reach out.
Do VC firms in San Francisco only invest locally?
No. Most venture firms headquartered in San Francisco invest across regions, though many favor startups they can meet in person. Check each firm's thesis for geographic focus.

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