Wireframe Ventures — Pre-Seed & Seed VC Firm ($500K–$2.0M Checks)
Wireframe Ventures is a Pre-Seed, Seed venture capital firm based in San Francisco, California, United States investing in AI / ML, Enterprise, Other. The firm typically writes $500K–$2.0M checks and has 44 portfolio companies in our records.
- Check size
- $500K–$2.0M
- Portfolio
- 44 companies on record
- Partners
- 5 listed
- AUM
- $77M
- Stage
- Pre-Seed, Seed
- Sectors
- AI / ML, Enterprise, Other, SaaS
- HQ
- San Francisco, California, United States
Last verified: 2026-10-06
Pre-Seed, Seed
$500K – $2.0M
$77M
44+ companies
5 partners
Investment Thesis
Wireframe invests at pre-seed and seed in mission-driven founders using technology to improve human health and the planet, with a focus including climate, bio, and health.
How Wireframe Ventures invests
Wireframe Ventures is a vc firm based in San Francisco, California, United States. The firm invests at the Pre-Seed, Seed stages, with a focus on AI / ML, Enterprise, Other, SaaS.
Wireframe Ventures typically writes checks of $500K–$2.0M per investment, backed by approximately $77M in assets under management.
Investing since at least 2005, Wireframe Ventures has backed 44 companies in our records, including Caladan Bio, Cocoon Carbon, Sora Fuel. Its most recent recorded investment was in 2024.
Partners & Team
Zachary Vella
GP
Industry Focus
Invests In
Portfolio Companies (44)
2024
Caladan Bio
Next-generation benchtop bioreactors for synthetic biology
Cocoon Carbon
Erasing the environmental cost of construction by removing millions of tonnes of CO2 & waste from heavy industry
Sora Fuel
An infinitely scalable pathway to sustainable aviation fuels - made from just air, water, and renewable energy
2023
Passkey Therapeutics
Unlocking biological complexity to discover better medicines
Pasture Biosciences
Vaccinating cows to reduce harmful methane emissions, a major accelerant of climate change
Tembo
Dev-first, fully-extensible managed Postgres
SirenOpt
Sensors and software to improve manufacturing yield and performance of micro- and nano-scale materials
2022
Tyba
Digital infrastructure for electrical market participation.
Canopy Climate
Climate benefits for every company. Canopy makes it easy for employees to get to net zero carbon at home.
Zivian
Empowering compliant healthcare collaborations
- •Raising at Pre-Seed, Seed? You're squarely in their sweet spot.
- •Lead with your fit in AI / ML, Enterprise, Other — the sectors they actively back.
- •Size your ask to their typical $500K – $2.0M check.
- •warm intro preferred
- •Address your outreach to a specific partner, such as Harsh Patel, Cofounder.
- •A warm introduction beats a cold email. Get matched and request an intro.
Featured In
Browse More Investors
Fundraising resources
Frequently Asked Questions
See if Wireframe Ventures is a match for your startup
Upload your pitch deck to see how well you match with Wireframe Ventures and 10,000+ other investors.
Ask your AI assistant about this investor: connect InvestorMatch to Claude or ChatGPT
Is this your profile? Request a correction or removal