WI

Wireframe Ventures — Pre-Seed & Seed VC Firm ($500K–$2.0M Checks)

VC
San Francisco, California, United StatesWebsite

Wireframe Ventures is a Pre-Seed, Seed venture capital firm based in San Francisco, California, United States investing in AI / ML, Enterprise, Other. The firm typically writes $500K–$2.0M checks and has 44 portfolio companies in our records.

Check size
$500K–$2.0M
Portfolio
44 companies on record
Partners
5 listed
AUM
$77M
Stage
Pre-Seed, Seed
Sectors
AI / ML, Enterprise, Other, SaaS
HQ
San Francisco, California, United States

Last verified: 2026-10-06

How to approach: warm intro preferred
Stage

Pre-Seed, Seed

Check Size

$500K – $2.0M

AUM

$77M

Portfolio

44+ companies

Team

5 partners

Investor activity
Last known investment: 2024Investments in last 12 months: 0

Investment Thesis

Wireframe invests at pre-seed and seed in mission-driven founders using technology to improve human health and the planet, with a focus including climate, bio, and health.

How Wireframe Ventures invests

Wireframe Ventures is a vc firm based in San Francisco, California, United States. The firm invests at the Pre-Seed, Seed stages, with a focus on AI / ML, Enterprise, Other, SaaS.

Wireframe Ventures typically writes checks of $500K–$2.0M per investment, backed by approximately $77M in assets under management.

Investing since at least 2005, Wireframe Ventures has backed 44 companies in our records, including Caladan Bio, Cocoon Carbon, Sora Fuel. Its most recent recorded investment was in 2024.

Partners & Team

HP

Harsh Patel

Cofounder

ClimateTech
Biotech
Energy
Health
DeepTech / Hardware
H

Harsh

Investor

Harsh brings a lifetime of wisdom coupled with uncanny insight, empathy, and authentic conviction to his investments. He is single-handedly the 'accelerator' you wished existed.

LB

Lily Bernicker

Partner

ClimateTech
Bio / Health
Health Policy
Value-based care models
PS

Paul Straub

Managing Partner

AgTech
ClimateTech/CleanTech
EnergyTech
HealthIT
Impact
IoT
ZV

Zachary Vella

GP

AI/ML
Enterprise

Industry Focus

Invests In

AI / ML
Enterprise
Other
SaaS

Portfolio Companies (44)

2024

CA

Caladan Bio

Biotech·Seed

Next-generation benchtop bioreactors for synthetic biology

CO

Cocoon Carbon

Climate Tech·Seed

Erasing the environmental cost of construction by removing millions of tonnes of CO2 & waste from heavy industry

SO

Sora Fuel

Climate Tech·Seed

An infinitely scalable pathway to sustainable aviation fuels - made from just air, water, and renewable energy

2023

PA

Passkey Therapeutics

Biotech·Seed

Unlocking biological complexity to discover better medicines

PA

Pasture Biosciences

Climate Tech·Seed

Vaccinating cows to reduce harmful methane emissions, a major accelerant of climate change

TE

Tembo

Developer Tools·Seed

Dev-first, fully-extensible managed Postgres

SI

SirenOpt

Manufacturing Tech·Seed

Sensors and software to improve manufacturing yield and performance of micro- and nano-scale materials

2022

TY

Tyba

Energy Tech·Seed

Digital infrastructure for electrical market participation.

CA

Canopy Climate

Climate Tech·Seed

Climate benefits for every company. Canopy makes it easy for employees to get to net zero carbon at home.

ZI

Zivian

Healthcare·Pre-seed

Empowering compliant healthcare collaborations

How to pitch Wireframe Ventures
  • •Raising at Pre-Seed, Seed? You're squarely in their sweet spot.
  • •Lead with your fit in AI / ML, Enterprise, Other — the sectors they actively back.
  • •Size your ask to their typical $500K – $2.0M check.
  • •warm intro preferred
  • •Address your outreach to a specific partner, such as Harsh Patel, Cofounder.
  • •A warm introduction beats a cold email. Get matched and request an intro.

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