UP

Upstream Collective

VC
San Francisco, CA, USA

Upstream Collective is a Pre-Seed, Seed venture capital firm based in San Francisco, CA, USA investing in Marketplace, Healthcare, SaaS. The firm typically writes $250K–$3.0M checks and has 2 portfolio companies in our records.

Check size
$250K–$3.0M
Portfolio
2 companies on record
Partners
1 listed
Stage
Pre-Seed, Seed
Sectors
Marketplace, Healthcare, SaaS, Enterprise, Developer Tools, Consumer
HQ
San Francisco, CA, USA
AUM
Not in our records

Last verified: 2026-04-12

How to approach: warm intro preferred
Stage

Pre-Seed, Seed

Check Size

$250K – $3.0M

Portfolio

2+ companies

Team

1 partner

Investor activity
Investments in last 12 months: 0

Investment Thesis

Upstream Collective invests in early-stage marketplace innovations and workflow software improving health and commerce infrastructures.

How Upstream Collective invests

Upstream Collective is a vc firm based in San Francisco, CA, USA. The firm invests at the Pre-Seed, Seed stages, with a focus on Marketplace, Healthcare, SaaS, Enterprise, Developer Tools. It does not invest in Consumer products.

Upstream Collective typically writes checks of $250K–$3.0M per investment.

Upstream Collective has backed 2 companies in our records, including CareSync, VendorHub.

Partners & Team

ET

Emily Tran

GP

Marketplaces
HealthTech

Industry Focus

Invests In

Marketplace
Healthcare
SaaS
Enterprise
Developer Tools
Consumer

Does Not Invest In

Consumer products

Portfolio Companies (2)

Other

CA

CareSync

HealthTech
VE

VendorHub

B2B SaaS
How to pitch Upstream Collective
  • Raising at Pre-Seed, Seed? You're squarely in their sweet spot.
  • Lead with your fit in Marketplace, Healthcare, SaaS — the sectors they actively back.
  • Size your ask to their typical $250K – $3.0M check.
  • warm intro preferred
  • Address your outreach to a specific partner, such as Emily Tran, GP.
  • A warm introduction beats a cold email. Get matched and request an intro.

Featured In

Browse More Investors

Fundraising resources

Frequently Asked Questions

See if Upstream Collective is a match for your startup

Upload your pitch deck to see how well you match with Upstream Collective and 10,000+ other investors.

Is this your profile? Request a correction or removal