Series A Venture Capital Firms

AlignThesis backs startups proving measurable productivity gains in enterprise environments, including vertical SaaS targeting HR and people operations.

• Other
• SaaS
• Enterprise

• Seed, Series A
• $700K – $5.0M
• Chicago, IL
• 2 portfolio companies

Aligned Alpha backs startups enabling efficiency in supply chain commerce and B2B buyer-seller pathways across niche markets in MENA and Africa.

• Other

• Seed, Series A
• $750K – $5.0M
• Abu Dhabi, UAE
• 2 portfolio companies

Focuses exclusively on transforming healthcare delivery for low-income and Medicaid populations using value-based care models and GovTech innovation.

• Healthcare
• Other

• Seed, Series A
• $750K – $5.0M
• Boston, MA
• 1 portfolio company

Invests exclusively in startups pioneering transformative advanced material and electronic architecture innovations.

• Other

• Seed, Series A
• $750K – $3.0M
• Boston, MA
• 2 portfolio companies

Allegion Ventures invests in technologies transforming property management, security, and automation.

• Real Estate
• Other
• Enterprise

• Pre-Seed, Seed, Series A
• $250K – $2.0M
• Dublin, Ireland and Carmel, IN
• 2 portfolio companies

Pre-seed, Seed, Series A tech startups across USA & Canada.

• SaaS
• Fintech
• Other

• Pre-Seed, Seed, Series A
• $100K – $350K
• 87 portfolio companies

Early-stage enterprise tech investor focused on software and data-driven systems for business transformation.

• Enterprise
• Other
• SaaS

• Seed, Series A
• $500K – $5.0M
• Palo Alto, CA
• 3 portfolio companies

Invests in software-driven healthcare transformation, especially AI-enabled tools that improve operating leverage in care delivery. Good fit for back-office automation and practice management software...

• Healthcare
• AI / ML
• Other

• Seed, Series A
• US
• 33 portfolio companies

Ally Bridge Group is dedicated to innovative life science investments, including pharmaceutical technologies and cloud-enabled health solutions.

• Healthcare
• Other

• Pre-Seed, Seed, Series A
• $200K – $5.0M
• Hong Kong, China
• 26 portfolio companies

HealthTech venture fund focused on digital health companies. A fit for patient-facing health platforms and healthcare workflow products.

• Healthcare
• EdTech

• Pre-Seed, Seed, Series A
• Israel
• 8 portfolio companies

Focuses on platforms solving consumer pain points via marketplace models.

• Marketplace
• Other

• Seed, Series A
• $250K – $1.0M
• Los Angeles, CA
• 8 portfolio companies

Invests at the intersection of enterprise SaaS and AI/ML innovation, targeting scalable B2B solutions.

• SaaS
• AI / ML

• seed+, Series A
• $1.5M – $3.0M
• New York, NY
• 12 portfolio companies

Accelerating innovation in the future of food through investments in sustainable FoodTech solutions.

• Food / AgTech
• Other

• Seed, Series A
• $150K – $1.0M
• New York, NY

Focuses on early-stage investments in technology-driven startups in Indonesia and broader Southeast Asia, with deep ties to FMCG and retail.

• Enterprise
• Other

• Seed, Series A
• $500K – $3.0M
• Jakarta, Indonesia
• 35 portfolio companies

Alpha Matrix Partners invests in software and AI-driven tools specifically targeted toward financial innovation and alternative data applications.

• Other

• Seed, Series A
• $500K – $4.0M
• Austin, TX
• 1 portfolio company

Focuses on early-stage investments in AI-backed solutions transforming B2B marketing, sales, and customer engagement strategies.

• Other
• AI / ML
• SaaS

• Seed, Series A
• $300K – $1.5M
• Chicago, IL
• 2 portfolio companies

AlphaPixel Ventures focuses on transformations in AI-powered consumer devices and SaaS-enabled hardware, catering to innovative DTC startups.

• Other

• Pre-Seed, Seed, Series A
• $1.0M – $3.0M
• NYC, NY
• 1 portfolio company

Focuses on B2B SaaS startups leveraging data and AI-driven automation.

• SaaS
• Marketplace
• AI / ML

• Seed, Series A
• $300K – $2.0M
• New York, NY
• 2 portfolio companies

Focuses exclusively on startups advancing brain health and disease prevention using neurotechnology and machine learning.

• Other
• Healthcare

• Series A, Seed
• $3.0M – $12.0M
• San Francisco, CA
• 2 portfolio companies

Invests in blockchain-native infrastructure and platforms enabling institutional capital flows into digital assets.

• Other

• Seed, Series A
• $1.0M – $10.0M
• Austin, TX
• 1 portfolio company

Focused on startups reshaping capital markets and enabling broader access to alternative investments.

• Other
• Fintech

• Seed, Series A
• $750K – $3.5M
• Boston, MA
• 1 portfolio company

Focuses on emerging HealthTech startups in the Southeast U.S., prioritizing scalable SaaS solutions.

• Other
• Healthcare
• SaaS

• Pre-Seed, Seed, Series A
• $250K – $1.5M
• Atlanta, GA
• 1 portfolio company

A sports and software-focused fund that explicitly backs computer-vision-enabled sports businesses. It is one of the clearest niche matches for AI-based sports video analytics and automated highlight ...

• Other

• Seed, Series A
• Oslo, Norway

Invests in early-stage companies solving critical challenges in the aerospace and advanced manufacturing sectors, with a focus on enabling U.S.-based production capacity.

• Other

• Seed, Series A
• $250K – $2.0M
• Denver, CO
• 1 portfolio company