Series A AI & Machine Learning Venture Capital Firms

Early-stage firm investing in digital health and data/security infrastructure, including healthcare IT and enterprise SaaS.

• Healthcare
• Other
• Security

• Seed, Series A
• $750K – $6.0M
• Boston, MA
• 97 portfolio companies

Operator-led enterprise fund investing in technical B2B software, including security and infrastructure products. Helpful for founders needing enterprise GTM and scaling support.

• Enterprise
• Security
• Developer Tools

• Seed, Series A
• $500K – $3.0M
• San Francisco, CA
• 13 portfolio companies

511 Ventures focuses on AI-enabled enterprise infrastructure and tools aimed at safety, stability, and optimization within high-consequence B2B verticals.

• Other
• Deep Tech
• SaaS

• Seed, Series A
• $250K – $2.5M
• Boston, MA
• 1 portfolio company

ACME Capital supports early-stage companies modernizing infrastructure, enterprise technologies, and industrial workflows.

• SaaS
• AI / ML
• Other

• Seed, Series A
• $1.0M – $3.0M
• San Francisco, CA
• 8 portfolio companies

Backing AI-driven technologies across industries, with a key emphasis on enterprise and B2B intelligence solutions.

• AI / ML
• SaaS

• seed+, Series A
• $1.0M – $5.0M
• San Francisco, CA
• 37 portfolio companies

Invests in startups using AI to spearhead innovations in cybersecurity, enhancing threat detection and response capabilities.

• Security
• Other
• AI / ML

• Seed, Series A
• $500K – $3.0M
• Chicago, IL
• 16 portfolio companies

AI First Capital specializes in early-stage companies using artificial intelligence to solve industry-specific problems, focusing on verticalized AI applications.

• AI / ML
• SaaS
• Other

• Pre-Seed, Seed, Series A
• $500K – $3.0M
• Palo Alto, CA
• 8 portfolio companies

Specializes in climate-resilient tech and sustainable infrastructure for industrial and global applications.

• Other
• Developer Tools
• AI / ML

• Seed, Series A
• $1.0M – $5.0M
• Singapore
• 2 portfolio companies

Focused exclusively on transformative healthcare technology solutions that address hospital challenges and improve care delivery via AI and SaaS models.

• Other
• Healthcare
• SaaS

• Seed+, Series A
• $3.0M – $10.0M
• Boston, MA
• 2 portfolio companies

Investing in groundbreaking startups in AI-enabled platforms, consumer social products, and creator ecosystems globally.

• AI / ML
• Other
• Marketplace

• Pre-Seed, Seed, Series A
• $500K – $5.0M
• Sydney, Australia
• 49 portfolio companies

Stealth fund backing AI-first SaaS companies that solve tangible everyday productivity challenges.

• Other
• SaaS
• AI / ML

• Seed, Series A
• $500K – $5.0M
• San Francisco, CA
• 31 portfolio companies

Focused on Enterprise SaaS, infrastructure, and tools enabling AI-driven workflows for regulated industries.

• Enterprise
• Other
• SaaS

• Seed, Series A
• $500K – $3.0M
• San Francisco, CA
• 47 portfolio companies

Focuses on ventures rethinking the future of commerce and retail sustainability, including furniture, home goods, and fashion.

• Other
• Climate / Energy
• AI / ML

• Seed, Series A
• $500K – $3.0M
• Chicago, IL
• 16 portfolio companies

Invests at the intersection of enterprise SaaS and AI/ML innovation, targeting scalable B2B solutions.

• SaaS
• AI / ML

• seed+, Series A
• $1.5M – $3.0M
• New York, NY
• 12 portfolio companies

Focuses on early-stage investments in AI-backed solutions transforming B2B marketing, sales, and customer engagement strategies.

• Other
• AI / ML
• SaaS

• Seed, Series A
• $300K – $1.5M
• Chicago, IL
• 2 portfolio companies

Invests in companies building data-driven and AI-disrupted infrastructures, with a specialization in trading and financial systems.

• AI / ML
• Other
• Fintech

• Seed, Series A
• $1.0M – $10.0M
• San Francisco, CA
• 2 portfolio companies

Focuses on B2B SaaS startups leveraging data and AI-driven automation.

• SaaS
• Marketplace
• AI / ML

• Seed, Series A
• $300K – $2.0M
• New York, NY
• 2 portfolio companies

Multi-fund platform investing in venture-backed startups at seed and beyond, often co-investing in priced seed rounds.

• Other
• Healthcare
• AI / ML

• Seed, Series A
• $250K – $3.0M
• Manchester, NH
• 34 portfolio companies

Amadeus invests in companies building disruptive technologies in AI/ML, healthcare tech, and SaaS with global potential.

• AI / ML
• Healthcare
• SaaS

• Seed, Series A
• $1.0M – $5.0M
• Cambridge, UK
• 49 portfolio companies

Focuses on enabling Africa’s transition from labor-intensive industries to knowledge-driven technologies powered by AI and education platforms.

• AI / ML
• EdTech
• Other

• Seed, Series A
• $250K – $1.0M
• Nairobi, Kenya
• 17 portfolio companies

Arbor Impact invests in startups driving the circular economy through sustainable building materials and advanced manufacturing.

• Other
• AI / ML
• SaaS

• Seed, Series A
• $250K – $5.0M
• Chicago, IL
• 67 portfolio companies

Argonautic Ventures invests in first-principled fintech and blockchain solutions solving real-world pain points.

• Fintech
• Other
• SaaS

• Seed, Series A
• $250K – $2.0M
• Salt Lake City, UT
• 7 portfolio companies

Focused on data-first platforms and SaaS tools leveraging analytics to solve high-value enterprise challenges across industries.

• Other
• AI / ML
• SaaS

• Seed, Series A
• $500K – $3.0M
• New York, NY
• 75 portfolio companies

Focused on emerging protocols leveraging decentralization, interoperability, and stablecoin adoption in APAC.

• Other
• AI / ML
• Developer Tools

• Seed, Series A
• $750K – $3.0M
• Sydney, Australia
• 18 portfolio companies