Series A AI & Machine Learning Venture Capital Firms

Early-stage firm investing in digital health and data/security infrastructure, including healthcare IT and enterprise SaaS.

• Healthcare
• Other
• Security

• Seed, Series A
• $750K – $6.0M
• Boston, MA
• 88 portfolio companies

Operator-led enterprise fund investing in technical B2B software, including security and infrastructure products. Helpful for founders needing enterprise GTM and scaling support.

• Enterprise
• Security
• Developer Tools

• Seed, Series A
• $500K – $3.0M
• San Francisco, CA
• 8 portfolio companies

511 Ventures focuses on AI-enabled enterprise infrastructure and tools aimed at safety, stability, and optimization within high-consequence B2B verticals.

• Other
• Deep Tech
• SaaS

• Seed, Series A
• $250K – $2.5M
• Boston, MA
• 1 portfolio company

ACME Capital supports early-stage companies modernizing infrastructure, enterprise technologies, and industrial workflows.

• SaaS
• AI / ML
• Other

• Seed, Series A
• $1.0M – $3.0M
• San Francisco, CA
• 8 portfolio companies

Backing AI-driven technologies across industries, with a key emphasis on enterprise and B2B intelligence solutions.

• AI / ML
• SaaS

• seed+, Series A
• $1.0M – $5.0M
• San Francisco, CA
• 37 portfolio companies

Invests in startups using AI to spearhead innovations in cybersecurity, enhancing threat detection and response capabilities.

• Security
• Other
• AI / ML

• Seed, Series A
• $500K – $3.0M
• Chicago, IL
• 16 portfolio companies

Dedicated to advancing AI-centric fintech startups that improve financial workflows, debt solutions, and operational efficiencies.

• AI / ML
• Fintech
• Other

• Seed, Series A
• $1.0M – $7.0M
• Atlanta, GA
• 2 portfolio companies

AI First Capital specializes in early-stage companies using artificial intelligence to solve industry-specific problems, focusing on verticalized AI applications.

• AI / ML
• SaaS
• Other

• Pre-Seed, Seed, Series A
• $500K – $3.0M
• Palo Alto, CA
• 8 portfolio companies

Focused on government utilization of AI to improve public services and operations within government agencies.

• AI / ML
• Other

• Series A
• $1.5M – $12.0M
• Chicago, IL

Specializes in AI-driven industrial inspection technologies that enhance operational safety and efficiency.

• Other
• AI / ML

• Seed, Series A
• $300K – $3.5M
• Boston, MA
• 1 portfolio company

Invests in AI-native platforms with infrastructural applications for enterprise software systems and integrations.

• AI / ML
• SaaS

• Seed, Series A
• $500K – $3.0M
• New York, NY
• 1 portfolio company

Focuses exclusively on companies propelling AI technologies for use cases in marketing and enterprise visibility solutions.

• SaaS
• Other
• AI / ML

• Seed, Series A
• $1.0M – $3.0M
• Toronto, Canada
• 1 portfolio company

Targets AI-driven SaaS solutions with data analytics components that transform business operations.

• AI / ML
• Developer Tools
• SaaS

• Series A
• $5.0M – $10.0M
• Austin, TX

AI Ventures Foundry is a micro-fund investing exclusively in AI-driven enterprises with a strong B2B SaaS model, focusing on early-stage investments.

• AI / ML
• SaaS
• Enterprise

• Series A
• $2.5M – $4.0M
• San Francisco, CA
• 16 portfolio companies

Focuses on AI investments that drive efficiencies in industrial sectors, including logistics.

• AI / ML
• Other

• Seed, Series A
• $500K – $3.0M
• Boston, MA

Invests in early-stage companies using AI to transform manufacturing processes and capabilities.

• AI / ML
• Other
• SaaS

• Pre-Seed, Seed, Series A
• $300K – $3.0M
• Tokyo, Japan
• 2 portfolio companies

Specialized in AI/ML startups with productivity-focused applications, especially those targeting operational efficiency in commerce and logistics sectors.

• AI / ML
• Other

• Seed, Series A
• $500K – $3.0M
• New York, NY
• 3 portfolio companies

Specializes in climate-resilient tech and sustainable infrastructure for industrial and global applications.

• Other
• Developer Tools
• AI / ML

• Seed, Series A
• $1.0M – $5.0M
• Singapore
• 2 portfolio companies

Focused exclusively on transformative healthcare technology solutions that address hospital challenges and improve care delivery via AI and SaaS models.

• Other
• Healthcare
• SaaS

• Seed+, Series A
• $3.0M – $10.0M
• Boston, MA
• 2 portfolio companies

Fostering early-stage innovations in agricultural technology through strategic funding of startups poised to optimize food supply chains.

• Food / AgTech
• Fintech
• AI / ML

• Seed, Series A
• $500K – $3.0M
• London, UK
• 1 portfolio company

Investing in groundbreaking startups in AI-enabled platforms, consumer social products, and creator ecosystems globally.

• AI / ML
• Other
• Marketplace

• Pre-Seed, Seed, Series A
• $500K – $5.0M
• Sydney, Australia
• 49 portfolio companies

They invest in early-stage, AI-native companies (Pre-seed through Series A) where artificial intelligence is core to the product and competitive moat, across sectors like developer tools/infrastructur...

• Other
• SaaS
• AI / ML

• Seed, Series A
• $750K – $5.0M
• Newark, California, USA
• 31 portfolio companies

Akkadian Ventures is a venture secondary investment firm that provides liquidity to founders, employees, and early investors, and invests across primary and secondary private-technology transactions, ...

• Enterprise
• Other
• SaaS

• Seed, Series A
• $250K – $10.0M
• San Francisco, California, United States
• 47 portfolio companies

Focuses on ventures rethinking the future of commerce and retail sustainability, including furniture, home goods, and fashion.

• Other
• Climate / Energy
• AI / ML

• Seed, Series A
• $500K – $3.0M
• Chicago, IL
• 16 portfolio companies