TW

Two Sigma Ventures

VC
US-NYCWebsite

Two Sigma Ventures is a Seed, Series A, Series B venture capital firm based in US-NYC investing in AI / ML, Developer Tools, Enterprise. The firm typically writes $1.0M–$25.0M checks and has 30 portfolio companies in our records.

Check size
$1.0M–$25.0M
Portfolio
30 companies on record
Partners
6 listed
AUM
$1.8B
Stage
Seed, Series A, Series B
Sectors
AI / ML, Developer Tools, Enterprise, Fintech, Other
HQ
US-NYC

Last verified: 2026-06-25

Stage

Seed, Series A, Series B

Check Size

$1.0M – $25.0M

AUM

$1.8B

Portfolio

30+ companies

Team

6 partners

Investor activity
Investments in last 12 months: 0

Investment Thesis

Investing in data-driven companies solving hard problems.

How Two Sigma Ventures invests

Two Sigma Ventures is a vc firm based in US-NYC. The firm invests at the Seed, Series A, Series B stages, with a focus on AI / ML, Developer Tools, Enterprise, Fintech, Other.

Two Sigma Ventures typically writes checks of $1.0M–$25.0M per investment, backed by approximately $1.8B in assets under management.

Two Sigma Ventures has backed 30 companies in our records, including 3DR, Amper Music, Anomalo.

Partners & Team

MP

Mark Pickering

Managing Director

AI
Data
MJ

Matt Jacobus

Venture Partner

SC

Sidney Costabile

Partner

AM

Alessandra Massa

Marketing Manager

RT

Riz Thakir

SVP of Finance

CB

Colin Beirne

Managing Director

Industry Focus

Invests In

AI / ML
Developer Tools
Enterprise
Fintech
Other

Portfolio Companies (30)

Other

3D

3DR

AM

Amper Music

AN

Anomalo

AN

Ansel Health

AP

Appia Bio

AR

Arda

BA

Bark

BO

Boundless

C3

C3

CA

Cajal Therapeutics

How to pitch Two Sigma Ventures
  • Raising at Seed, Series A, Series B? You're squarely in their sweet spot.
  • Lead with your fit in AI / ML, Developer Tools, Enterprise — the sectors they actively back.
  • Size your ask to their typical $1.0M – $25.0M check.
  • Address your outreach to a specific partner, such as Mark Pickering, Managing Director.
  • A warm introduction beats a cold email. Get matched and request an intro.

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