NI

Niche Innovation Fund

VC
New York, NYWebsite

Niche Innovation Fund is a Pre-Seed venture capital firm based in New York, NY investing in Other, SaaS. The firm typically writes $75K–$200K checks and has 11 portfolio companies in our records.

How to approach: cold outreach ok
Stage

Pre-Seed

Check Size

$75K – $200K

Portfolio

11+ companies

Team

1 partner

Investor activity
Last known investment: 2025Investments in last 12 months: 9

Investment Thesis

Focused on niche innovations in the creator economy, promoting interoperability and scalability.

How Niche Innovation Fund invests

Niche Innovation Fund is a vc firm based in New York, NY. The firm invests at the Pre-Seed stage, with a focus on Other, SaaS. It does not invest in Healthcare.

Niche Innovation Fund typically writes checks of $75K–$200K per investment.

Investing since at least 2023, Niche Innovation Fund has backed 11 companies in our records, including SpotRx (Medicated Adhesive Stickers), CTHRC1-Targeting Antibodies for Colorectal Cancer, NewGown. Its most recent recorded investment was in 2025, with 9 investments logged over the last 12 months.

Meet the Team

DR

Daniela Roth

Managing Partner

Creator Economy
SaaS

Industry Focus

Invests In

Other
SaaS

Does Not Invest In

Healthcare

Portfolio Companies (11)

2025

SP

SpotRx (Medicated Adhesive Stickers)

Other·PROBLEM

Many skin conditions include small areas which are difficult to treat with conventional topicals.

CT

CTHRC1-Targeting Antibodies for Colorectal Cancer

Immunotherapy and Cancer Diagnostics·Executive Statement

Innovative antibodies targeting the immune checkpoint molecule CTHRC1 offer new therapeutic and diagnostic options for colorectal cancer.

NE

NewGown

Other·PROBLEM

Patients with altered mental status often have additional medical needs requiring lines and/or tubes for care.

ME

Methods to Inhibit Fatty Acid Binding Proteins (FABPs) for Cancer Treatment

Biomedical Therapeutics – Cancer Research·Executive Statement

Targeting and inhibiting FABPs offers a novel therapeutic strategy to reduce tumor growth and improve cancer patient outcomes.

PO

Portable Workstation

Medical Device·PROBLEM

Home health providers often have difficulty setting up supplies in unconventional spaces, such as bedrooms and living rooms.

CO

Comfort Bra

Other·PROBLEM

Regulations require a ligature-free or resistant environment for patients who present to the ED and are at risk for suicide.

CO

Compliant, Temperature-Stable Balloon for Use in Percutaneous Ablation Procedures

Medical Device·PROBLEM

A barrier to the percutaneous treatment of solid organ intraabdominal tumors during cryoablation or microwave ablation is often the presence of adjacent temperature-sensitive structures.

BR

Breast Biopsy Clips

Medical Device·PROBLEM

At MaineHealth Breast Care and Cancer Supportive Care -Scarborough, over 1,500 procedures annually require biopsy marker placement.

NE

Neck Saver Laptop Holder

Medical Device·PROBLEM

Many clinicians perform patient care and documentation on laptops, causing clinicians to sustain abnormal neck postures to view the screen.

2023

HA

Halter-Clip

Medical Device·PROBLEM

Gastrostomy tubes (G-tubes) are feeding tubes that are placed surgically through the abdomen directly into the stomach.

How to pitch Niche Innovation Fund
  • Raising at Pre-Seed? You're squarely in their sweet spot.
  • Lead with your fit in Other, SaaS — the sectors they actively back.
  • Size your ask to their typical $75K – $200K check.
  • cold outreach ok
  • Address your outreach to a specific partner, such as Daniela Roth, Managing Partner.
  • A warm introduction beats a cold email. Get matched and request an intro.

Featured In

Browse More Investors

Fundraising resources

Frequently Asked Questions

See if Niche Innovation Fund is a match for your startup

Upload your pitch deck to see how well you match with Niche Innovation Fund and 10,000+ other investors.

Is this your profile? Request a correction or removal