Niche Innovation Fund
Niche Innovation Fund is a Pre-Seed venture capital firm based in New York, NY investing in Other, SaaS. The firm typically writes $75K–$200K checks and has 11 portfolio companies in our records.
Pre-Seed
$75K – $200K
11+ companies
1 partner
Investment Thesis
Focused on niche innovations in the creator economy, promoting interoperability and scalability.
How Niche Innovation Fund invests
Niche Innovation Fund is a vc firm based in New York, NY. The firm invests at the Pre-Seed stage, with a focus on Other, SaaS. It does not invest in Healthcare.
Niche Innovation Fund typically writes checks of $75K–$200K per investment.
Investing since at least 2023, Niche Innovation Fund has backed 11 companies in our records, including SpotRx (Medicated Adhesive Stickers), CTHRC1-Targeting Antibodies for Colorectal Cancer, NewGown. Its most recent recorded investment was in 2025, with 9 investments logged over the last 12 months.
Meet the Team
Daniela Roth
Managing Partner
Industry Focus
Invests In
Does Not Invest In
Portfolio Companies (11)
2025
SpotRx (Medicated Adhesive Stickers)
Many skin conditions include small areas which are difficult to treat with conventional topicals.
CTHRC1-Targeting Antibodies for Colorectal Cancer
Innovative antibodies targeting the immune checkpoint molecule CTHRC1 offer new therapeutic and diagnostic options for colorectal cancer.
NewGown
Patients with altered mental status often have additional medical needs requiring lines and/or tubes for care.
Methods to Inhibit Fatty Acid Binding Proteins (FABPs) for Cancer Treatment
Targeting and inhibiting FABPs offers a novel therapeutic strategy to reduce tumor growth and improve cancer patient outcomes.
Portable Workstation
Home health providers often have difficulty setting up supplies in unconventional spaces, such as bedrooms and living rooms.
Comfort Bra
Regulations require a ligature-free or resistant environment for patients who present to the ED and are at risk for suicide.
Compliant, Temperature-Stable Balloon for Use in Percutaneous Ablation Procedures
A barrier to the percutaneous treatment of solid organ intraabdominal tumors during cryoablation or microwave ablation is often the presence of adjacent temperature-sensitive structures.
Breast Biopsy Clips
At MaineHealth Breast Care and Cancer Supportive Care -Scarborough, over 1,500 procedures annually require biopsy marker placement.
Neck Saver Laptop Holder
Many clinicians perform patient care and documentation on laptops, causing clinicians to sustain abnormal neck postures to view the screen.
2023
Halter-Clip
Gastrostomy tubes (G-tubes) are feeding tubes that are placed surgically through the abdomen directly into the stomach.
- •Raising at Pre-Seed? You're squarely in their sweet spot.
- •Lead with your fit in Other, SaaS — the sectors they actively back.
- •Size your ask to their typical $75K – $200K check.
- •cold outreach ok
- •Address your outreach to a specific partner, such as Daniela Roth, Managing Partner.
- •A warm introduction beats a cold email. Get matched and request an intro.
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