Main Sequence Ventures — Pre-Seed & Seed VC Firm ($250K–$5.0M Checks)
Main Sequence Ventures is a Pre-Seed, Seed, Series A venture capital firm based in Sydney, New South Wales investing in Deep Tech, Other, Climate / Energy. The firm typically writes $250K–$5.0M checks and has 63 portfolio companies in our records.
- Check size
- $250K–$5.0M
- Portfolio
- 63 companies on record
- Partners
- 11 listed
- AUM
- $500M
- Stage
- Pre-Seed, Seed, Series A
- Sectors
- Deep Tech, Other, Climate / Energy, AI / ML, Enterprise, SaaS
- HQ
- Sydney, New South Wales
Last verified: 2026-10-26
Pre-Seed, Seed, Series A
$250K – $5.0M
$500M
63+ companies
11 partners
Investment Thesis
Main Sequence backs deep tech companies solving hard industrial and climate problems, including synthetic biology and advanced manufacturing. The firm is known for supporting platform technologies that improve unit economics and scale in complex production environments.
How Main Sequence Ventures invests
Main Sequence Ventures is a vc firm based in Sydney, New South Wales. The firm invests at the Pre-Seed, Seed, Series A stages, with a focus on Deep Tech, Other, Climate / Energy, AI / ML, Enterprise.
Main Sequence Ventures typically writes checks of $250K–$5.0M per investment, backed by approximately $500M in assets under management. Our records include 3 funds raised by the firm.
Main Sequence Ventures has backed 63 companies in our records, including levur, arkeus ai, xylo.
Partners & Team
Unknown
GP
Elaine Stead
Partner
Promoted to Partner as firm builds toward Fund 4
Industry Focus
Invests In
Funds
Main Sequence Ventures Fund III
Main Sequence Ventures Fund II
Main Sequence Ventures Fund I
Recent Activity
Raised Main Sequence Ventures Fund III ($200M)
2020 · fund records
Raised Main Sequence Ventures Fund II ($150M)
2016 · fund records
Raised Main Sequence Ventures Fund I ($100M)
2012 · fund records
Portfolio Companies (63)
Other
levur
Brewing a Sustainable Alternative to Palm Oil.
arkeus ai
Accelerating decision making through the fusion of optics and autonomy.
xylo
Psychedelic medicine to treat mental illness.
number8bio
Decarbonising the planet with synthetic biology.
rainstick
Combining traditional knowledge with modern technology for plants and fungi.
jdoodle
Programming ecosystem for the AI era.
plotlogic
The future of natural resource mining: greater recovery, less waste.
arlula
Harnessing earth observation data for critical decision making.
rios
Reinventing factory automation with robotics and AI.
inventia life science
Revolutionising 3D cell biology.
- •Raising at Pre-Seed, Seed, Series A? You're squarely in their sweet spot.
- •Lead with your fit in Deep Tech, Other, Climate / Energy — the sectors they actively back.
- •Size your ask to their typical $250K – $5.0M check.
- •warm intro preferred
- •Address your outreach to a specific partner, such as Gabrielle Munzer, Partner.
- •A warm introduction beats a cold email. Get matched and request an intro.
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