DI

Discovery Node Equity

VC
Berlin, GermanyWebsite
How to approach: cold outreach ok
Stage

Seed

Check Size

$500K – $1.5M

Portfolio

13+ companies

Team

4 partners

Investor activity
Investments in last 12 months: 0

Investment Thesis

Pioneers early-stage investments in blockchain scalability solutions and fintech innovation.

How Discovery Node Equity invests

Discovery Node Equity is a vc firm based in Berlin, Germany. The firm invests at the Seed stage, with a focus on Other, Fintech, AI / ML, Developer Tools.

Discovery Node Equity typically writes checks of $500K–$1.5M per investment.

Discovery Node Equity has backed 13 companies in our records, including ChainLinker, Mindback Therapeutics, Pixium Vision.

Meet the Team

MW

Markus Weber

GP

Blockchain
B2B SaaS
GL

Guillen Lopez

Partner

venture capital
technology
life sciences entrepreneurship
artificial intelligence
gene therapy
nanotechnology

He holds an MBA from the London School of Business and has studied biomedical engineering at Paris Sciences Lettres University. Before transitioning to venture capital, Guillen was a co-founder of Mindback Therapeutics, and previously he worked in R&D in bioengineering, AI, and robotics. Guillen was also a corporate tech strategy executive and a researcher at the French Space Agency. He was commissioned by the United Nations’ UNESCO and ITU task forces to find technologies to mitigate the impacts of disasters.

SP

Serge Picaud

Partner

life science incubator
biotech
gene therapy
drug discovery

Dr. Picaud has over 30 years of experience as an inventor, researcher, and entrepreneur. He is the Director of the successful Paris based life science incubator Vision Institute and is also aProfessor at the University Sorbonne in Paris. Dr. Picaud has founded several biotech companies including Pixium Vision (retinal electronic implant, IPO Euronext), GenSight Biologics (gene therapy platform, IPO Euronext), Fovea Pharmaceuticals (drug discovery platform, acquired by Sanofi and Gamut Therapeutics (gene and cell therapy, acquired by Sparing Vision). In addition, having held positions at the University of Berkeley and the Max Planck Institute Dr. Picaud also holds over 20 patents and has over 400 academic publications.

AS

Andrea Spezzi

Partner

neurodegeneration
pharmaceutical medicine
venture capital
private equity
clinical development
commercialization

Andrea is an international executive, entrepreneur, founder and investor, with more than 20 years of experience in the industry. Since June 2024, she has been Senior Executive Board Director overseeing the development division at JCR and advisor/board members in several startups. Andrea was co-founder, president and CEO and executive board member of a discovery stage start-up, Rejuvitas Inc, based in NYC with focus on neurodegeneration. She Co-founded and was CMO of Orchard Therapeutics, while taking the company to IPO with a valuation of $1.2B; she led the development and registration and commercialization of Libmeldy™, for metachromatic leukodystrophy and Strimvelis® for adenosine deaminase severe combined immunodeficiency (ADA-SCID), as well as the development of other neurometabolic diseases like MPSI and MPSIIIA. She was VP and Medicine Development Leader at the GSK Rare Diseases Unit, leading the metabolic pipeline and early development of IZCARGO® for MPSII, in collaboration with JCR Pharmaceuticals, and the Pulmonary Artery Hypertension pipeline that developed and registered Flolan ph12 and Volibris® in collaboration with Gilead. She worked as global medical director at Takeda R&D in the metabolic and cardiovascular unit and at Hammersmith Medicine Research (HMR), a phase I/II unit, as a Research Physician, in London UK. She worked as a pediatrician before moving to industry. Andrea is a Physician and Pediatrician, Specialist in Pharmaceutical Medicine. Fellow of the Faculty of Pharmaceutical Medicine in UK (FFPM). Graduated from Columbia University Business School Emeritus Program in venture capital and private equity. Member of the Board of Examiners of the Faculty of Pharmaceutical Medicine, London, UK. Andrea was nominated by BioBeat as an Alumni on Patient impact in 2020, Nominated by NGP Capital as one of the most well-funded venture-backed women founder’s companies in the US, Europe, and China in 2020; Movers and Shakers in BioBusiness 2020; one of the 2018’s Fiercest Women in Life Sciences and as one of the UK 50 movers and shakers more influential women in the industry in 2016.

Industry Focus

Invests In

Other
Fintech
AI / ML
Developer Tools

Portfolio Companies (13)

Other

CH

ChainLinker

Blockchain Infrastructure
MI

Mindback Therapeutics

PI

Pixium Vision

GE

GenSight Biologics

FO

Fovea Pharmaceuticals

GA

Gamut Therapeutics

RE

Rejuvitas Inc

OR

Orchard Therapeutics

JC

JCR Pharmaceuticals

TA

Takeda R&D

How to pitch Discovery Node Equity
  • Raising at Seed? You're squarely in their sweet spot.
  • Lead with your fit in Other, Fintech, AI / ML — the sectors they actively back.
  • Size your ask to their typical $500K – $1.5M check.
  • cold outreach ok
  • Address your outreach to a specific partner, such as Markus Weber, GP.
  • A warm introduction beats a cold email. Get matched and request an intro.

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