DE

Define Ventures

VC
San Francisco, CAWebsite

Define Ventures is a Seed, Series A venture capital firm based in San Francisco, CA investing in Healthcare. The firm typically writes $1.5M–$10.0M checks and has 8 portfolio companies in our records.

Check size
$1.5M–$10.0M
Portfolio
8 companies on record
Partners
1 listed
AUM
$800M
Stage
Seed, Series A
Sectors
Healthcare
HQ
San Francisco, CA

Last verified: 2026-05-16

How to approach: warm intro preferred
Stage

Seed, Series A

Check Size

$1.5M – $10.0M

AUM

$800M

Portfolio

8+ companies

Team

1 partner

Investor activity
Investments in last 12 months: 0

Investment Thesis

Specializes in early-stage digital health companies focused on transforming healthcare delivery and technology solutions.

How Define Ventures invests

Define Ventures is a vc firm based in San Francisco, CA. The firm invests at the Seed, Series A stages, with a focus on Healthcare.

Define Ventures typically writes checks of $1.5M–$10.0M per investment, backed by approximately $800M in assets under management.

Define Ventures has backed 8 companies in our records, including Equip Health, BetterUp, Hims & Hers.

Partners & Team

LC

Lynne Chou O’Keefe

Founder and Managing Partner

HealthTech
Digital Health
Early-stage

Industry Focus

Invests In

Healthcare

Portfolio Companies (8)

Other

EQ

Equip Health

Healthcare Delivery
BE

BetterUp

Mental HealthTech
HI

Hims & Hers

Health & Wellness

The leading health & wellness platform, on a mission to help the world feel great

UN

Unite Us

Connecting community through technology and improving whole-person health at scale

CO

Cohere Health

Leveraging AI & ML to improve the complex clinical care experience for HEALTH PLANS, providers, and patients

FO

FOLX Health

The first digital healthcare and wellness platform for the LGBTQIA+ community

WA

Waltz Health

BL

Blackbird Health

How to pitch Define Ventures
  • Raising at Seed, Series A? You're squarely in their sweet spot.
  • Lead with your fit in Healthcare — the sectors they actively back.
  • Size your ask to their typical $1.5M – $10.0M check.
  • warm intro preferred
  • Address your outreach to a specific partner, such as Lynne Chou O’Keefe, Founder and Managing Partner.
  • A warm introduction beats a cold email. Get matched and request an intro.

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