Series A AI & Machine Learning Venture Capital Firms

Focused exclusively on investing in innovations that advance neuroscience and brain health, leveraging AI and digital tools.

• Other
• Healthcare
• AI / ML

• Series A, early-growth
• $2.5M – $10.0M
• 2 portfolio companies

Targets cutting-edge educational tech solutions tailored for school systems.

• EdTech
• AI / ML

• Series A
• $500K – $2.0M
• New York, NY
• 31 portfolio companies

Investing in groundbreaking semiconductor technologies to power the next wave of AI and data processing innovations.

• Other
• AI / ML

• Seed, Series A
• $2.0M – $5.0M
• Boston, MA
• 1 portfolio company

Enterprise-focused seed investor backing software founders, including fintech infrastructure and workflow automation companies.

• SaaS
• Fintech
• AI / ML

• Pre-Seed, Seed, Series A
• Newark, NJ
• 16 portfolio companies

Investing in the future of retail technology with a focus on scalable E-commerce solutions.

• Other
• AI / ML
• Food / AgTech

• Seed, Series A
• $1.0M – $5.0M
• New York, NY
• 3 portfolio companies

Investing in seed-stage companies redefining the future of workforce enablement with innovative HRTech and training solutions, particularly AI-assisted tools.

• Other
• AI / ML
• SaaS

• Seed, Series A
• $500K – $5.0M
• Chicago, IL
• 2 portfolio companies

Invests in technology businesses that create essential infrastructure and long-term economic value, including in emerging markets.

• Developer Tools
• Climate / Energy
• Other

• Seed, Series A
• $250K – $3.0M
• London, United Kingdom
• 13 portfolio companies

Targets Retail Tech startups in the Nordics and DACH region, especially those building infrastructure solutions for brick-and-mortar stores.

• Other
• SaaS
• AI / ML

• Pre-Seed, Seed, Series A
• $200K – $4.0M
• Stockholm, Sweden
• 21 portfolio companies

Broad technology and healthcare investor with exposure to hospital software and operational AI. Best suited as a strategic expansion investor once traction is visible.

• Healthcare
• AI / ML
• Enterprise

• Seed, Series A
• Menlo Park, California
• 15 portfolio companies

NovaWave Capital supports European SaaS startups streamlining B2B processes, with a specific interest in recruitment and talent marketplaces.

• SaaS
• Marketplace
• Other

• Pre-Seed, Seed, Series A
• $250K – $2.0M
• Amsterdam, Netherlands
• 2 portfolio companies

Africa-focused VC investing in high-impact companies, with a long track record in inclusive fintech.

• Other
• Fintech
• Healthcare

• Seed, Series A
• $500K – $4.0M
• Nairobi, Kenya
• 26 portfolio companies

Early-stage medtech and life sciences investor focusing on chronic disease therapeutics and diagnostics, including molecular diagnostics and advanced imaging, in Europe and the US.

• Other
• Developer Tools
• Consumer

• Seed, Series A
• 5 portfolio companies

Seed-stage digital health specialist focused on care delivery innovation and digital health infrastructure.

• Healthcare
• AI / ML
• EdTech

• Seed, Series A
• $250K – $1.5M
• Chicago, IL
• 35 portfolio companies

Obvious Ventures invests thematically across three pillars—planetary health, human health, and economic health—backing exceptional founders building breakthrough, world-positive companies that transfo...

• Consumer
• Healthcare
• Climate / Energy

• Seed, Series A
• $5.0M – $12.0M
• San Francisco, United States
• 10 portfolio companies

OpenSky Ventures focuses on B2B software, data, and cloud infrastructure. The fund often supports technical founders tackling enterprise workflow and systems challenges.

• Enterprise
• Developer Tools
• AI / ML

• Seed, Series A
• Boston, MA
• 4 portfolio companies

Invests in HealthTech startups delivering measurable improvements in clinical outcomes through software and AI-driven solutions.

• Healthcare
• AI / ML
• Other

• Series A, Seed
• $1.5M – $10.0M
• Palo Alto, CA
• 4 portfolio companies

Optum Ventures invests from seed through growth in companies at the intersection of healthcare and technology, including value-based care delivery, enterprise software and enabling infrastructure, and...

• Healthcare
• AI / ML

• Seed, Series A
• $1.5M – $5.0M
• Boston, Massachusetts, United States
• 1 portfolio company

Major life sciences investor with broad biotech and pharma coverage. Relevant mainly when a partner is championing an early-stage therapeutics opportunity.

• Healthcare
• Other
• AI / ML

• Seed, Series A
• New York, New York
• 109 portfolio companies

Builds and invests in early-stage HealthTech companies solving foundational pain points in healthcare infrastructure.

• Healthcare
• Other
• AI / ML

• Seed, Series A
• $1.0M – $5.0M
• New York, NY
• 10 portfolio companies

Newer web3-focused venture platform investing in blockchain, DeFi, and application-layer crypto startups.

• Other
• Developer Tools
• AI / ML

• Pre-Seed, Seed, Series A
• 15 portfolio companies

Investing in startups that address urban resilience, safety technologies, and compliance systems for waterfront property management.

• Real Estate
• Other
• SaaS

• Pre-Seed, Seed, Series A
• $500K – $4.0M
• Miami, Florida
• 29 portfolio companies

Focused on early-stage technology addressing infrastructure gaps and cultural needs in Africa, with an emphasis on government-backed solutions and tech-enabled media/distributed education.

• AI / ML
• Other
• EdTech

• Seed, Series A
• $250K – $2.5M
• Lagos, Nigeria
• 9 portfolio companies

Pantera invests across blockchain / digital assets — venture equity, private tokens, and liquid tokens — with a full-spectrum, capital-structure-agnostic model, focused on Seed to Series B, infrastruc...

• Other
• Developer Tools
• AI / ML

• Seed, Series A
• $100K – $5.0M
• San Francisco, California, USA
• 3 portfolio companies

Paragon Partners focuses on early-stage companies utilizing AI to disrupt enterprise solutions across various industry sectors.

• Other
• SaaS
• Consumer

• Seed, Series A
• $100K – $2.0M
• Sydney, Australia
• 25 portfolio companies