Pre-Seed Venture Capital Firms

Dedicated to early-stage HealthTech solutions leveraging AI and machine learning to optimize operations in hospitals and healthcare organizations.

• Healthcare
• Other
• Enterprise

• Pre-Seed, Seed
• $250K – $3.0M
• Austin, TX
• 1 portfolio company

Invests in operational tools and SaaS solutions tailored to startup enablement and enterprise workflows.

• Other

• Pre-Seed
• $300K – $750K
• Los Angeles, CA
• 204 portfolio companies

Focuses on operational-heavy B2B startups building scalable software platforms in SaaS or marketplaces.

• SaaS
• Marketplace
• Fintech

• Seed, Pre-Seed
• $250K – $2.0M
• Los Angeles, CA
• 2 portfolio companies

Operator-led micro fund focusing on early-stage B2B SaaS companies, particularly in productivity, leadership, and organizational tools.

• SaaS
• Other

• Pre-Seed, Seed
• $50K – $250K
• San Diego, CA
• 1 portfolio company

Operator-led investing with a bias toward practical software businesses. Relevant for products that solve deep workflow problems for specific customer segments.

• SaaS
• Other

• Pre-Seed, Seed
• New York, NY
• 1 portfolio company

A rolling fund backing early-stage startups building operational efficiency tools for retail and logistics.

• Other
• Consumer
• Marketplace

• Pre-Seed
• $250K – $1.3M
• Global
• 1 portfolio company

Specializes in funding early-stage automation technologies that optimize business operations for mid-market enterprises.

• SaaS
• Other
• Enterprise

• Pre-Seed, Seed
• $500K – $2.5M
• Chicago, IL
• 23 portfolio companies

Invests in early-stage RevOps and operational SaaS companies aiming to transform revenue-generating processes for mid-market and enterprise customers.

• Other
• SaaS
• Enterprise

• Pre-Seed, Seed
• $750K – $2.5M
• Seattle, WA
• 6 portfolio companies

Investing in startups that leverage technology to optimize supply chain and operational efficiencies.

• Other
• Enterprise
• AI / ML

• Pre-Seed, Seed
• $500K – $2.0M
• San Jose, California
• 1 portfolio company

Optica Venture Partners focuses on investing in cutting-edge optical computing technologies and AI infrastructure advancements.

• AI / ML
• Other
• Healthcare

• Pre-Seed, Seed
• $1.0M – $5.0M
• Cambridge, UK
• 7 portfolio companies

Investing in cutting-edge optical and sensor technologies for industrial use.

• Other
• Healthcare

• Pre-Seed, Seed
• $500K – $3.0M
• Chicago, IL
• 8 portfolio companies

Dedicated to enhancing AI infrastructure capabilities and investing in companies transforming machine learning efficiencies.

• AI / ML
• Developer Tools

• Pre-Seed, Seed
• $500K – $3.0M
• Boston, MA
• 5 portfolio companies

Focused on backing AI-driven B2B SaaS companies driving organizational efficiency and decision-making.

• Other
• SaaS
• AI / ML

• Pre-Seed, Seed
• $300K – $2.0M
• London, UK
• 2 portfolio companies

Optimizing supply chain operations through strategic investments in technology-driven startups, particularly those using AI and data analytics.

• Other

• Pre-Seed, Seed
• $200K – $1.0M
• Austin, TX

Focused on backing wellness and performance-driven SaaS products operating at the intersection of consumer and B2B.

• Healthcare
• Other
• SaaS

• Pre-Seed, Seed
• $500K – $2.5M
• 2 portfolio companies

Focuses on early-stage technology companies leveraging AI to create scalable SaaS solutions.

• SaaS
• AI / ML
• Enterprise

• Pre-Seed, Seed
• $1.0M – $3.0M
• Austin, TX
• 2 portfolio companies

Invests in AI-powered infrastructure software enabling scalable enterprise workflows, with focus on industries undergoing digital transformation.

• Other
• SaaS

• Pre-Seed, Seed
• $250K – $2.5M
• San Francisco, CA
• 2 portfolio companies

AI-focused venture fund built around foundational technologies, infrastructure, developer tools, and specialized frameworks. The strategy is aimed at software layers that underpin enterprise AI adopti...

• AI / ML
• Developer Tools
• Climate / Energy

• Pre-Seed, Seed
• 13 portfolio companies

Focuses on early-stage Web3 and crypto startups, leveraging a large LP base of YC alumni who actively support portfolio companies.

• Other
• EdTech
• Developer Tools

• Pre-Seed, Seed
• $50K – $500K
• Remote/Global
• 11 portfolio companies

Orbit Labs backs founders building productivity-focused B2B SaaS tools with AI/ML integration.

• SaaS
• Other
• Enterprise

• Pre-Seed, Seed
• $300K – $1.5M
• San Francisco, CA
• 39 portfolio companies

Orbit Partners invests in startups utilizing AI to enhance efficiency in sales and business operations within SMBs.

• AI / ML
• Other
• SaaS

• Pre-Seed, Seed
• $400K – $2.0M
• Toronto, Canada
• 5 portfolio companies

Invests in early-stage companies in Asia and emerging markets using AI to solve high-impact problems in visual data intelligence, logistics, and operational efficiency.

• AI / ML
• SaaS
• Other

• Pre-Seed, Seed
• $50K – $250K
• Singapore
• 2 portfolio companies

Focuses exclusively on early-stage companies innovating in aerospace and dual-use technologies.

• Other

• Pre-Seed
• $750K – $2.5M
• Los Angeles, CA
• 20 portfolio companies

Orbital specializes in data-driven B2B SaaS startups with global scalability potential, particularly CRM and customer retention platforms.

• SaaS
• Other

• Pre-Seed, Seed
• $200K – $3.0M
• London, UK
• 1 portfolio company