Series A AI & Machine Learning Venture Capital Firms

Browse 579 venture capital firms that invest in AI & Machine Learning startups at the Series A stage. Every firm is verified — explore their thesis, check size, and portfolio, then get matched with the best-fit investors for your startup.

Verified Series A AI & Machine Learning VC firms

Runtime Ventures

Invests in foundational software systems ensuring infrastructure integrity, AI safety, and deterministically reliable enterprise solutions.

  • Other
  • Enterprise
  • Developer Tools
  • Seed, Series A
  • $1.0M – $4.0M
  • Toronto, Canada
  • 36 portfolio companies

STV

Large Saudi technology investor with AI and software focus. More of a later-stage option, but relevant for strategic regional scaling if the startup quickly proves club demand.

  • AI / ML
  • SaaS
  • Enterprise
  • Seed, Series A, Series B
  • Riyadh, Saudi Arabia
  • 12 portfolio companies

STV

Focused on growing Saudi Arabia's innovation ecosystem, investing in scalable technologies including AI/ML and IoT.

  • AI / ML
  • Deep Tech
  • SaaS
  • Seed, Series A
  • $1.0M – $20.0M
  • Riyadh, Saudi Arabia
  • 2 portfolio companies

SaaS Boost Fund

Supports B2B SaaS startups solving operational inefficiencies with AI-driven platforms.

  • SaaS
  • Other
  • AI / ML
  • Pre-Seed, Seed, Series A
  • $750K – $5.0M
  • Boston, MA
  • 2 portfolio companies

SaaS Factory

Early-stage venture fund and operating platform focused on growing SaaS businesses through acquisition, investment, product management, and GTM execution. Very relevant to a product-and-GTM decision p...

  • SaaS
  • Other
  • AI / ML
  • Seed, Series A
  • 3 portfolio companies

SaaS Launch Group

Investing in early-stage B2B SaaS companies with disruptive AI solutions tailored for efficiency and scale in niche markets.

  • SaaS
  • AI / ML
  • Seed, Series A
  • $500K – $5.0M
  • Berlin, Germany
  • 1 portfolio company

SaaS Venture Studio Fund

Investing in subscription-based SaaS businesses with strong market differentiation, aiming to integrate scalable enterprise solutions.

  • SaaS
  • Enterprise
  • AI / ML
  • Seed, Series A
  • $500K – $3.0M
  • Austin, TX
  • 2 portfolio companies

SaaStr Fund

Fund dedicated exclusively to B2B/B2D/AI companies building business software, APIs, and tools that enable software creation. It is positioned for AI-native enterprise software with clear product-mark...

  • SaaS
  • AI / ML
  • Other
  • Seed, Series A
  • $750K – $5.0M
  • San Francisco, California
  • 13 portfolio companies

SafeTech Capital

Specializes in investing in the intersection of security tech and artificial intelligence, focusing on scalable solutions for enterprise deployments.

  • Other
  • AI / ML
  • Enterprise
  • Series A
  • $1.5M – $5.0M
  • Berlin, Germany
  • 1 portfolio company

Sales Enablement Ventures

Invests exclusively in enabling technologies that enhance sales processes, particularly in the B2B SaaS domain.

  • Other
  • SaaS
  • Enterprise
  • Series A
  • $500K – $15.0M
  • New York, NY
  • 10 portfolio companies

Sanara Capital

Dedicated health-tech fund investing in digital health, bio-convergence, and medical devices for Israeli-related startups in Israel and abroad. Positioned as a specialist platform with a portfolio spa...

  • Healthcare
  • Other
  • AI / ML
  • Seed, Series A, Series B, series-c
  • 22 portfolio companies

Sands Capital Ventures

Growth-oriented early-stage investor with a venture practice that backs enterprise software and select industrial technology companies.

  • Enterprise
  • Other
  • SaaS
  • Pre-Seed, Seed, Series A
  • $500K – $3.0M
  • Arlington, Virginia
  • 19 portfolio companies

Sapphire Sport (Sapphire Ventures)

Enterprise software specialist with an early-stage practice (Sapphire Sport) investing in seed/early rounds.

  • Enterprise
  • SaaS
  • Other
  • Seed, Series A
  • $1.0M – $3.0M
  • Palo Alto, CA
  • 6 portfolio companies

Sapphire Ventures

Global technology investment firm focused on enterprise software.

  • Enterprise
  • Healthcare
  • Fintech
  • Series A, Series B, Growth
  • $5.0M – $50.0M
  • US-SF
  • 66 portfolio companies

Savant

Participated in an AI Diagnostics round, implying some appetite for technical healthcare and diagnostic innovation.

  • Other
  • Security
  • Climate / Energy
  • Pre-Seed, Seed, Series A
  • 13 portfolio companies

ScOp Venture Capital

ScOp backs technical B2B software and deep-tech startups, with recent visibility in AI semiconductor design and verification through ChipAgents. The firm is a strong fit for pre-seed infrastructure so...

  • AI / ML
  • Other
  • SaaS
  • Pre-Seed, Seed, Series A
  • $250K – $2.0M
  • Santa Barbara, California
  • 40 portfolio companies

Scale Pilot Fund

Backing B2B solutions that optimize supply chains through AI and SaaS innovations.

  • AI / ML
  • Other
  • SaaS
  • Seed, Series A
  • $300K – $2.0M
  • London, UK

Scale Venture Partners

Partner with category-defining enterprise software companies.

  • Enterprise
  • SaaS
  • Developer Tools
  • Series A, Series B
  • $5.0M – $40.0M
  • US-SF
  • 29 portfolio companies

Scrub Capital

Early-stage US health care venture firm led by clinical operators; invests primarily up to $400K in pre-seed to Series A, avoiding high-regulation therapeutics/device classes. ([scrubcapital.com](http...

  • Healthcare
  • AI / ML
  • Pre-Seed, Seed, Series A
  • Up to $400K
  • US
  • 20 portfolio companies

Seaya Ventures

European venture platform with repeated exposure to mobility and transportation-related businesses, especially tech-enabled marketplaces and consumer internet models.

  • Other
  • Marketplace
  • Consumer
  • Seed, Series A
  • $250K – $5.0M
  • Madrid, Spain
  • 15 portfolio companies

Section 32

Focused on investing in AI-powered companies solving foundational business and marketing challenges.

  • AI / ML
  • SaaS
  • Seed, Series A
  • $2.0M – $5.0M
  • San Diego, CA
  • 2 portfolio companies

SecuraTech Capital

SecuraTech Capital invests in security technology innovations that leverage AI for enhanced enterprise and public sector protection.

  • Other
  • AI / ML
  • Series A
  • $3.0M – $5.0M
  • Dubai, UAE

Secure Ventures

Investing in breakthrough security technology firms leveraging AI to transform enterprise security and compliance.

  • Other
  • AI / ML
  • Series A
  • $2.0M – $5.0M
  • Los Angeles, CA

SecureNova Ventures

Targeted investments in pioneering GovTech and cybersecurity startups that aim to protect critical infrastructure.

  • Other
  • Security
  • AI / ML
  • Series A
  • $2.0M – $5.0M
  • Boston, MA
  • 1 portfolio company

Showing 433–456 of 579 firms — page 19 of 25.

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