Seed AI & Machine Learning Venture Capital Firms

Browse 2,906 venture capital firms that invest in AI & Machine Learning startups at the Seed stage. Every firm is verified — explore their thesis, check size, and portfolio, then get matched with the best-fit investors for your startup.

Verified Seed AI & Machine Learning VC firms

One Way Ventures

Invests in immigrant founders building scalable B2B and technical infrastructure solutions using AI.

  • Other
  • SaaS
  • Developer Tools
  • Pre-Seed, Seed
  • $250K – $2.0M
  • Boston, MA
  • 53 portfolio companies

OnePrime Capital

Small early-stage fund likely to focus on software and marketplace businesses with high founder access. Useful for seed rounds where operational help matters.

  • SaaS
  • Marketplace
  • AI / ML
  • Seed
  • 6 portfolio companies

Onstage Fund

Small European fund backing generative AI and B2B SaaS at the earliest stages. Well suited to software that automates business workflows and improves knowledge-work productivity.

  • Other
  • SaaS
  • AI / ML
  • Pre-Seed, Seed
  • $100K – $500K
  • Europe
  • 2 portfolio companies

Opal Seed Fund

Opal Seed Fund specializes in pre-seed investments in fintech innovation targeted at underserved and high-growth markets globally, with an emphasis on payments and remittances.

  • Other
  • Fintech
  • SaaS
  • Pre-Seed, Seed
  • $50K – $300K
  • London, UK
  • 5 portfolio companies

OpenAI Startup Fund

OpenAI’s startup fund backs ambitious AI-native companies building products with AI at the core. Best suited for technically strong founders in AI applications and infrastructure.

  • AI / ML
  • Seed
  • San Francisco, California

OpenAI Startup Fund

Targets innovative companies leveraging AI/ML technology for transformative development.

  • AI / ML
  • Other
  • Pre-Seed, Seed
  • $50K – $1.0M
  • San Francisco, CA
  • 1 portfolio company

OpenGov Ventures

Specialized in GovTech and AI for public sector optimization, including judicial digitization.

  • Other
  • AI / ML
  • Seed
  • $500K – $3.0M
  • San Francisco, CA
  • 1 portfolio company

OpenSky Ventures

OpenSky Ventures focuses on B2B software, data, and cloud infrastructure. The fund often supports technical founders tackling enterprise workflow and systems challenges.

  • Enterprise
  • Developer Tools
  • AI / ML
  • Seed, Series A
  • Boston, MA
  • 4 portfolio companies

Operational Analytics Fund

Focuses on funding next-gen operational analytics and AI-driven data tools for enterprise applications.

  • Other
  • AI / ML
  • Developer Tools
  • Seed, Pre-Seed
  • $300K – $4.0M
  • San Francisco, CA
  • 2 portfolio companies

Operational VC

Investing in modern tools for operations leaders at manufacturing enterprises; focusing on B2B SaaS companies disrupting procurement, logistics, and supply chain management.

  • Other
  • SaaS
  • Enterprise
  • Seed
  • $250K – $3.0M
  • Austin, TX
  • 1 portfolio company

Operator Health Ventures

Dedicated to early-stage HealthTech solutions leveraging AI and machine learning to optimize operations in hospitals and healthcare organizations.

  • Healthcare
  • Other
  • Enterprise
  • Pre-Seed, Seed
  • $250K – $3.0M
  • Austin, TX
  • 1 portfolio company

Ops Insight Capital

Focuses on startups leveraging IoT and AI to transform operational systems in manufacturing and energy.

  • Other
  • AI / ML
  • Seed
  • $750K – $2.5M
  • Boston, MA
  • 1 portfolio company

OpsMaven Capital

Invests in early-stage RevOps and operational SaaS companies aiming to transform revenue-generating processes for mid-market and enterprise customers.

  • Other
  • SaaS
  • Enterprise
  • Pre-Seed, Seed
  • $750K – $2.5M
  • Seattle, WA
  • 6 portfolio companies

OpsTech Capital

Investing in startups that leverage technology to optimize supply chain and operational efficiencies.

  • Other
  • Enterprise
  • AI / ML
  • Pre-Seed, Seed
  • $500K – $2.0M
  • San Jose, California
  • 1 portfolio company

Optica Venture Partners

Optica Venture Partners focuses on investing in cutting-edge optical computing technologies and AI infrastructure advancements.

  • AI / ML
  • Other
  • Healthcare
  • Pre-Seed, Seed
  • $1.0M – $5.0M
  • Cambridge, UK
  • 7 portfolio companies

Optify Health Partners

Invests in HealthTech startups delivering measurable improvements in clinical outcomes through software and AI-driven solutions.

  • Healthcare
  • AI / ML
  • Other
  • Series A, Seed
  • $1.5M – $10.0M
  • Palo Alto, CA
  • 4 portfolio companies

OptimAI Ventures

Dedicated to enhancing AI infrastructure capabilities and investing in companies transforming machine learning efficiencies.

  • AI / ML
  • Developer Tools
  • Pre-Seed, Seed
  • $500K – $3.0M
  • Boston, MA
  • 5 portfolio companies

Optimus Ventures

Focuses on early-stage technology companies leveraging AI to create scalable SaaS solutions.

  • SaaS
  • AI / ML
  • Enterprise
  • Pre-Seed, Seed
  • $1.0M – $3.0M
  • Austin, TX
  • 2 portfolio companies

Opto

AI-focused venture fund built around foundational technologies, infrastructure, developer tools, and specialized frameworks. The strategy is aimed at software layers that underpin enterprise AI adopti...

  • AI / ML
  • Developer Tools
  • Climate / Energy
  • Pre-Seed, Seed
  • 13 portfolio companies

Optum Ventures

Optum Ventures invests from seed through growth in companies at the intersection of healthcare and technology, including value-based care delivery, enterprise software and enabling infrastructure, and...

  • Healthcare
  • AI / ML
  • Seed, Series A
  • $1.5M – $5.0M
  • Boston, Massachusetts, United States
  • 1 portfolio company

OrbiMed

Major life sciences investor with broad biotech and pharma coverage. Relevant mainly when a partner is championing an early-stage therapeutics opportunity.

  • Healthcare
  • Other
  • AI / ML
  • Seed, Series A
  • New York, New York
  • 109 portfolio companies

Orbit Growth Partners

Supports e-commerce innovations that revolutionize digital selling and multi-channel retail operations.

  • Other
  • Marketplace
  • SaaS
  • Seed
  • $300K – $800K
  • New York, NY
  • 13 portfolio companies

Orbit Labs

Orbit Labs backs founders building productivity-focused B2B SaaS tools with AI/ML integration.

  • SaaS
  • Other
  • Enterprise
  • Pre-Seed, Seed
  • $300K – $1.5M
  • San Francisco, CA
  • 39 portfolio companies

Orbit Partners

Orbit Partners invests in startups utilizing AI to enhance efficiency in sales and business operations within SMBs.

  • AI / ML
  • Other
  • SaaS
  • Pre-Seed, Seed
  • $400K – $2.0M
  • Toronto, Canada
  • 5 portfolio companies

Showing 1921–1944 of 2906 firms — page 81 of 122.

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