Venture Capital Firms in San Francisco

First-check fund focused on software, AI, robotics, automation, and connected industrial systems for the manufacturing economy. Invests in pre-seed companies modernizing manufacturing with operational...

• Other
• Enterprise
• AI / ML

• Pre-Seed
• $700K – $1.0M
• San Francisco, California
• 12 portfolio companies

First-check fund backing pre-seed founders building software, AI, robotics, automation, and connected industrial systems that improve productivity across the manufacturing value chain.

• Other
• SaaS
• AI / ML

• Pre-Seed
• $700K – $1.0M
• San Francisco, California
• 12 portfolio companies

On Deck Angels backs mission-driven founders building category-defining consumer and software platforms, with a strong network of creators and operators.

• SaaS
• Other

• Pre-Seed
• $100K – $1.5M
• San Francisco, CA
• 21 portfolio companies

Invests in early-stage open-source software projects that have transformative potential in tech sectors.

• Other

• Seed
• $100K – $300K
• San Francisco, CA
• 1 portfolio company

Targets innovative companies leveraging AI/ML technology for transformative development.

• AI / ML
• Other

• Pre-Seed, Seed
• $50K – $1.0M
• San Francisco, CA
• 1 portfolio company

OpenAI’s startup fund backs ambitious AI-native companies building products with AI at the core. Best suited for technically strong founders in AI applications and infrastructure.

• AI / ML

• Seed
• San Francisco, California

Specialized in GovTech and AI for public sector optimization, including judicial digitization.

• Other
• AI / ML

• Seed
• $500K – $3.0M
• San Francisco, CA
• 1 portfolio company

Investing in open-source tools that empower developers and enterprise solutions at the pre-seed stage.

• Other
• Developer Tools
• SaaS

• Pre-Seed
• $75K – $150K
• San Francisco, CA
• 20 portfolio companies

Focuses on funding next-gen operational analytics and AI-driven data tools for enterprise applications.

• Other
• AI / ML
• Developer Tools

• Seed, Pre-Seed
• $300K – $4.0M
• San Francisco, CA
• 2 portfolio companies

Operators investing in early-stage enterprise SaaS and infrastructure with GTM execution support.

• SaaS
• Developer Tools

• Seed
• $500K – $5.0M
• San Francisco, CA
• 198 portfolio companies

FOG Ventures, the investing arm of Operators Guild, invests from pre-seed to pre-IPO in B2B software, infrastructure, and AI that power business operations, including finance, operations, go-to-market...

• Other
• Healthcare
• Consumer

• Seed
• $250K – $500K
• San Francisco, California, United States
• 17 portfolio companies

Invests in AI-powered infrastructure software enabling scalable enterprise workflows, with focus on industries undergoing digital transformation.

• Other
• SaaS

• Pre-Seed, Seed
• $250K – $2.5M
• San Francisco, CA
• 2 portfolio companies

Orbit Labs backs founders building productivity-focused B2B SaaS tools with AI/ML integration.

• SaaS
• Other
• Enterprise

• Pre-Seed, Seed
• $300K – $1.5M
• San Francisco, CA
• 39 portfolio companies

Invests in startups advancing geospatial mapping and AI applications for urban infrastructure and global development.

• Other
• AI / ML

• Pre-Seed, Seed
• $250K – $3.0M
• San Francisco, CA
• 1 portfolio company

Orion Blockchain Partners backs startups leveraging blockchain to improve transparency and compliance in financial services.

• Other
• Fintech

• Pre-Seed, Seed
• $200K – $500K
• San Francisco, CA

Focuses on compliant DeFi protocols, blockchain infrastructure, and institutional finance applications.

• Other

• Seed, Series A
• $1.0M – $5.0M
• San Francisco, CA
• 1 portfolio company

Operator-led pre-seed fund backing software and AI companies that automate workflows and improve productivity. This is a strong fit for an AI-native operating system that replaces fragmented manual ag...

• AI / ML
• SaaS
• Other

• Pre-Seed, Seed
• $250K – $1.5M
• San Francisco, CA
• 18 portfolio companies

Ovenblue Ventures specializes in startups innovating in food delivery models, restaurant optimization tech, and AI for logistics.

• Other
• AI / ML
• SaaS

• Pre-Seed
• $250K – $2.0M
• San Francisco, CA
• 2 portfolio companies

Largest education-focused venture firm; invests in education and workforce learning platforms, including enterprise upskilling.

• EdTech
• Other

• Pre-Seed, Seed
• $1.0M – $3.0M
• San Francisco, CA
• 14 portfolio companies

Corporate venture arm investing in digital operations, incident response, and enterprise workflow automation.

• Developer Tools
• SaaS
• Other

• Seed, Series A
• $250K – $2.0M
• San Francisco, CA
• 16 portfolio companies

Invests in innovations targeting the enhancement of social interaction and community experiences through software solutions.

• Other
• Consumer
• SaaS

• Pre-Seed, Seed
• $300K – $2.0M
• San Francisco, CA
• 8 portfolio companies

Pantera invests across blockchain / digital assets — venture equity, private tokens, and liquid tokens — with a full-spectrum, capital-structure-agnostic model, focused on Seed to Series B, infrastruc...

• Other
• Developer Tools
• AI / ML

• Seed, Series A
• $100K – $5.0M
• San Francisco, California, USA
• 3 portfolio companies

Paradigm says it builds and invests in crypto, AI, robotics, and other frontier technologies, from the earliest stages.

• Other

• Seed, Pre-Seed
• $1.0M – $10.0M
• San Francisco, United States
• 93 portfolio companies

Backs Indian founders building products for global markets, investing across early-stage sectors like B2B SaaS, Blockchain, AR/VR, CleanTech & DeepTech. ([crunchbase.com](https://www.crunchbase.com/or...

• Other
• AI / ML

• Pre-Seed, Seed
• $500K – $2.5M
• San Francisco, United States
• 2 portfolio companies