Series A Venture Capital Firms

Thrive State Ventures concentrates on transformative digital health and SaaS innovations that target niche medical markets.

• Healthcare
• SaaS
• Other

• Seed, Series A
• $750K – $3.5M
• Austin, TX
• 1 portfolio company

Solo-GP healthcare and technology investor focused on early-stage therapeutics, healthcare, and technology companies. The firm emphasizes value-added support and growth-oriented capital for early vent...

• Healthcare
• Other
• AI / ML

• Pre-Seed, Seed, Series A
• 13 portfolio companies

Cybersecurity-focused investor relevant for security platforms serving regulated and strategic environments. The defense angle increases compatibility with government and mission operations buyers.

• Security
• Other

• Pre-Seed, Seed, Series A
• null
• 17 portfolio companies

Invests in rapidly scaling B2B SaaS companies targeting enterprise markets with a unique focus on compounding customer insights.

• SaaS
• Enterprise

• Seed, Series A
• $1.0M – $5.0M
• Boston, MA
• 1 portfolio company

Tier 1 Capital backs innovative software startup founders tackling significant business challenges in the enterprise landscape.

• Enterprise

• Seed, Series A
• $250K – $2.0M
• Palo Alto, CA
• 1 portfolio company

Global investment firm focused on public and private markets.

• Enterprise
• Consumer
• Fintech

• Series A, Series B, Growth
• $10.0M – $500.0M
• US-NYC

Multi-stage investor with a long history of backing high-growth software/internet companies, including selective early-stage checks.

• Other
• Enterprise

• Seed, Series A
• $1.0M – $3.0M
• New York, NY
• 3 portfolio companies

Toba Capital invests in SaaS and enterprise software companies with products designed for SMBs and mid-market customers.

• SaaS
• Other

• Seed, Series A, Series B
• $1.0M – $10.0M
• Newport Beach, CA
• 43 portfolio companies

Impact investing.

• SaaS
• Developer Tools

• Series A, Seed
• Seattle, WA

Dedicated to supporting startups at the intersection of blockchain, consumer experiences, and tokenized rewards.

• Other
• Consumer

• Seed, Series A
• $750K – $2.5M
• Los Angeles, CA
• 2 portfolio companies

Invests in startups at the intersection of healthcare and blockchain, particularly those solving payment inefficiencies or cross-border medical challenges.

• Other
• Healthcare
• SaaS

• Seed, Series A
• $500K – $3.0M
• Austin, TX
• 1 portfolio company

TokenSpace Ventures focuses entirely on blockchain-based systems and AI tools to enable crypto trading and marketplace solutions.

• Other
• AI / ML

• Seed, Series A
• $250K – $2.0M
• Berlin, Germany
• 2 portfolio companies

Enterprise software-focused firm investing in B2B companies building mission-critical products.

• Enterprise
• SaaS
• Other

• Series A, Seed
• $3.0M – $10.0M
• Seattle, WA
• 3 portfolio companies

Fund-of-funds and venture investor with exposure to early-stage healthcare and technology managers and companies. It can be relevant through syndicate relationships more than pure thesis specializatio...

• Healthcare
• AI / ML
• Other

• Seed, Series A
• $250K – $5.0M
• San Francisco, CA
• 7 portfolio companies

Focuses on data-rich companies improving workflows for businesses and end consumers.

• SaaS
• Other

• Seed, Series A
• $500K – $5.0M
• New York, NY
• 1 portfolio company

Focused on innovation in InsurTech, including underwriting and risk quantification solutions.

• Other
• Fintech
• Security

• Seed, Series A
• $500K – $3.0M
• Los Angeles, CA
• 1 portfolio company

Invests in healthcare technology and service businesses in the U.S. that use innovation—particularly AI—and policy-aligned operating models to improve outcomes and lower costs for underserved communit...

• Other
• Healthcare

• Seed, Series A, Series B
• $3.0M – $30.0M
• New York, United States
• 5 portfolio companies

Invests broadly across frontier technology with strong interest in AI, robotics, software, and industrial applications. Backed by an automotive and manufacturing powerhouse with strategic relevance to...

• AI / ML
• Other
• Climate / Energy

• Seed, Series A
• $1.4M – $126.0M
• Los Altos, California
• 23 portfolio companies

Early-stage fund investing in frontier tech including robotics, autonomy, and AI with strong real-world applications.

• Other
• AI / ML

• Seed, Series A, pre_seed
• $500K – $5.0M
• San Francisco, CA
• 89 portfolio companies

Investing in startups developing measurable solutions for marketing performance in e-commerce and creator-driven growth.

• Other
• SaaS

• Seed, Series A
• $1.0M – $3.5M
• Boston, MA
• 1 portfolio company

Invests in enabling technologies that improve sales workflows and relationship mapping for high-PQ organizational users.

• Other
• SaaS

• Seed, Series A
• $500K – $5.0M
• New York, NY
• 2 portfolio companies

A recently launched fund targeting seed-stage SaaS solutions that address enterprise pain points in operations and financing.

• SaaS
• Other
• Enterprise

• Seed, Series A
• $250K – $5.0M
• Denver, CO
• 1 portfolio company

Backing trailblazing companies building infrastructure for the outdoor economy, including commerce marketplaces, AI systems for gear retail, and adventure-related startups.

• Other

• Seed, Series A
• $1.0M – $5.0M
• Denver, CO
• 2 portfolio companies

Invests in startups transforming transportation and logistics through technology, with an emphasis on TMS and freight brokerage.

• Other

• Seed, Series A
• $250K – $2.0M
• Chicago, IL
• 1 portfolio company