Series A AI & Machine Learning Venture Capital Firms

Multi-stage VC firm focused on accelerating disruptive innovations and trends.

• Enterprise
• Consumer
• Healthcare

• Seed, Series A, Series B
• $1.0M – $50.0M
• US-SF
• 29 portfolio companies

Lightspeed backs technical companies across AI infrastructure and enterprise software. It is appropriate for a standout seed company with broad platform potential.

• AI / ML
• Enterprise
• Other

• Seed, Series A
• $500K – $7.0M
• Menlo Park, California
• 7 portfolio companies

Targets early-stage innovators using AI to bridge language divides in education, media, and international commerce markets.

• Other
• AI / ML
• EdTech

• Seed, Series A
• $500K – $7.0M
• London, UK
• 1 portfolio company

Invests in AI-driven B2B software across regulated sectors including defense, govtech, and legaltech. The firm’s thesis centers on emerging-growth software with strong workflow automation and infrastr...

• AI / ML
• SaaS
• Other

• Seed, Series A
• 6 portfolio companies

Lotus Capital focuses on healthcare innovations and B2B SaaS solutions that improve operational efficiencies and patient outcomes across Asia.

• Healthcare
• SaaS
• Security

• Seed, Series A
• $1.0M – $5.0M
• Bangkok, Thailand
• 8 portfolio companies

Travel-tech investor identified as an active fund in the sector through sector tracking sources. Likely to be interested in travel infrastructure and booking workflows, especially where AI improves co...

• Other
• Healthcare
• AI / ML

• Seed, Series A
• 9 portfolio companies

Luma Capital invests in trailblazing customer service tech and SMB SaaS startups that redefine business-client interactions.

• Other
• SaaS
• Enterprise

• Pre-Seed, Seed, Series A
• $500K – $4.0M
• Denver, CO
• 4 portfolio companies

Corporate-backed specialist fund investing in biotech, life sciences tools, and enabling technologies with global reach including US startups.

• Healthcare
• Other
• AI / ML

• Seed, Series A
• $500K – $3.0M
• Amsterdam, Netherlands
• 126 portfolio companies

Investing in blockchain projects across the MENA region, with a special interest in those aligning with Islamic finance principles.

• Other
• AI / ML

• Series A
• $2.0M – $6.0M
• Dubai, UAE
• 2 portfolio companies

A $50M early-stage fund backing frontier hardware, robotics, automation, and industrial AI companies. The fund is designed to support seed and early-stage teams building the next generation of physica...

• Other
• AI / ML
• Developer Tools

• Pre-Seed, Seed, Series A
• $500K – $1.5M
• Silicon Valley, California
• 7 portfolio companies

Invests in early-stage startups building tools and infrastructure for machine learning operations.

• Other
• AI / ML
• SaaS

• Seed, Series A
• $1.0M – $4.0M
• Austin, TX
• 1 portfolio company

Invests in early-stage (Seed and Series A) European tech companies—particularly enterprise AI, data infrastructure, fintech, cloud and data-driven health—using a research-led thesis, with hands-on ope...

• AI / ML
• SaaS
• Healthcare

• Seed, Series A
• $1.0M – $5.0M
• London, United Kingdom
• 3 portfolio companies

Insurance-led venture platform investing in digital transformation across carriers, risk, underwriting, and insurance data systems.

• Other
• AI / ML
• Developer Tools

• Seed, Series A
• Menlo Park, CA
• 135 portfolio companies

Specialized in investing in next-gen machine learning companies scaling AI tools for enterprise applications.

• AI / ML
• SaaS
• Other

• Seed, Series A
• $500K – $2.5M
• London, UK
• 2 portfolio companies

Investing in B2B SaaS solutions tailored to large-scale manufacturing processes, machined part production, and procurement optimization.

• Other
• SaaS
• Enterprise

• Seed, Series A
• $750K – $3.5M
• Detroit, MI
• 1 portfolio company

Madrona backs visionary founders building transformational tech companies, with a deep focus on applied AI (domain-specific applications & infrastructure), developer tools, enterprise software, and AI...

• Enterprise
• Developer Tools
• SaaS

• Seed, Series A
• $1.0M – $15.0M
• Seattle, Washington, USA
• 13 portfolio companies

Exclusively focused on investments in logistics and maritime software solutions, with a strong preference for early-stage global ventures.

• Other
• Developer Tools
• AI / ML

• Seed, Series A
• $750K – $5.0M
• Oslo, Norway
• 23 portfolio companies

Specializes in backing early-stage platforms that create marketplaces addressing logistics and enterprise pain points.

• Marketplace
• Other
• SaaS

• Seed, Series A
• $500K – $7.0M
• 2 portfolio companies

Matador Ventures invests in startups in AI/ML Ops and developer tools that refine engineering productivity and workflow optimization.

• Other
• Developer Tools
• Enterprise

• Seed, Series A
• $250K – $1.5M
• Austin, TX
• 1 portfolio company

Early-stage venture capital. Backing founders building transformative companies.

• Enterprise
• Consumer
• Fintech

• Seed, Series A
• $1.0M – $20.0M
• US-SF
• 29 portfolio companies

Top-tier firm with a strong record in enterprise software and AI. Relevant partner-level backing can be compelling for infrastructure-like software that becomes mission critical to operators.

• Enterprise
• AI / ML
• Other

• Seed, Series A
• $1.0M – $4.0M
• San Francisco, California
• 13 portfolio companies

Supports seed-stage and growth companies in B2B SaaS and AI innovation, with interest in enterprise data solutions and compliance-heavy workflows.

• SaaS
• Enterprise
• AI / ML

• Seed, Series A
• $1.0M – $8.0M
• Glasgow, UK
• 1 portfolio company

Mayfield backs AI-first founders from day zero, investing across the layers of its Cognition-as-a-Service stack.

• AI / ML
• Enterprise
• SaaS

• Seed, Series A
• $1.0M – $4.0M
• Menlo Park, California, United States

Strategic investor backing chip design and semiconductor innovation relevant to MediaTek’s product ecosystem.

• Other
• AI / ML

• Seed, Series A
• Hsinchu, Taiwan