Pre-Seed Venture Capital Firms

Invests in early-stage Web3 / crypto / decentralized-technology projects around the world, especially at Pre-Seed / Seed stages, emphasizing long-term partnership with technical founders.

• Other
• Developer Tools

• Pre-Seed, Seed
• $100K – $5.0M
• New York City, United States
• 9 portfolio companies

Symphonic Ventures invests in cutting-edge B2B fintech and AI infrastructure startups that aim to disrupt legacy financial systems and enable machine-to-machine financial transactions.

• Fintech
• AI / ML
• Other

• Pre-Seed, Seed
• $1.0M – $3.0M
• Austin, TX
• 20 portfolio companies

Focuses on synthetic biology and next-gen healthcare tools for accelerated R&D processes.

• Other
• Healthcare

• Pre-Seed
• $500K – $3.0M
• San Francisco, CA
• 1 portfolio company

Dedicated to startups in synthetic biology and advanced biomaterials sectors, focusing on early-stage investments.

• Healthcare
• Other

• Pre-Seed, Seed
• $100K – $300K
• 1 portfolio company

Focused on early-stage companies developing cutting-edge biotechnologies and pharmaceutical innovations.

• Other
• Healthcare

• Pre-Seed, Seed
• $750K – $2.5M
• Boston, MA
• 10 portfolio companies

Focused on seed-stage startups leveraging IoT-driven solutions to enable smarter industrial operations and compliance processes.

• Other
• SaaS

• Seed, Pre-Seed
• $200K – $1.5M
• Austin, TX
• 1 portfolio company

Funding innovations in SaaS platforms that leverage AI for healthcare solutions.

• Healthcare
• AI / ML
• SaaS

• Pre-Seed
• $500K – $2.5M
• Austin, TX
• 1 portfolio company

Invests in innovative supply chain management solutions integrated with enterprise software to enhance operational efficiency.

• Other
• Enterprise

• Pre-Seed
• $1.0M – $3.0M
• Austin, TX

Investing in early-stage AI technologies with applications in education and personalized learning experiences.

• AI / ML
• EdTech
• Enterprise

• Pre-Seed
• $500K – $1.0M
• Austin, TX
• 5 portfolio companies

Invests in AI and media technology startups that integrate advanced AI for transformative media applications.

• Other
• AI / ML
• SaaS

• Pre-Seed
• $100K – $500K
• Johannesburg, South Africa
• 6 portfolio companies

SyncFlow Capital targets innovative B2B SaaS platforms that enhance enterprise efficiency and collaboration.

• SaaS
• Enterprise
• Other

• Pre-Seed
• $250K – $1.0M
• Chicago, IL
• 6 portfolio companies

Invests in high-potential, transformative SaaS and social interaction platforms, especially those leveraging network effects.

• SaaS
• Other
• Enterprise

• Pre-Seed
• $250K – $500K
• Dubai, UAE
• 1 portfolio company

Synchrony Ventures targets disruptive enterprise software startups in Europe, focusing on accounting automation and tools that enhance financial efficiency.

• Enterprise
• Other
• SaaS

• Pre-Seed, Seed
• $500K – $2.5M
• Berlin, Germany
• 9 portfolio companies

Focused on empowering B2B SaaS companies in fintech with disruptive potential.

• SaaS
• Fintech

• Pre-Seed
• $1.0M – $3.5M
• Chicago, IL

Invests in early-stage research tool innovations with a focus on improving academic workflows and collaboration.

• Other
• SaaS

• Pre-Seed
• $1.0M – $3.0M
• Chicago, IL
• 1 portfolio company

Investing exclusively in the DevOps and developer tools ecosystem, Syntax Ventures backs early-stage companies building infrastructure for modern software development.

• Developer Tools
• Other

• Pre-Seed, Seed
• $250K – $2.0M
• Austin, TX
• 2 portfolio companies

Invests in tech-forward solutions solving fundamental healthcare and mental health challenges through SaaS and AI-driven approaches.

• Healthcare
• SaaS
• Other

• Pre-Seed, Seed
• $250K – $1.5M
• London, UK
• 14 portfolio companies

Invests in innovative startups building synthetic worlds, blending gaming, AI, and blockchain technologies to power decentralized and immersive virtual environments.

• Other
• AI / ML

• Pre-Seed, Seed
• $50K – $250K
• Singapore
• 2 portfolio companies

Investing in startups enhancing system observability and incident management capabilities for enterprise IT teams.

• Other
• Enterprise
• SaaS

• Pre-Seed
• $100K – $300K
• San Francisco, CA
• 1 portfolio company

System Initiative specializes in tools, platforms, and infrastructure supporting automation and developer productivity.

• Other
• Developer Tools
• Enterprise

• Pre-Seed, Seed
• $200K – $2.0M
• San Francisco, CA
• 2 portfolio companies

Emerging fund backing infrastructure-first startups that solve engineering bottlenecks using AI-powered solutions.

• Other
• Developer Tools
• AI / ML

• Pre-Seed, Seed
• $300K – $1.5M
• Chicago, IL
• 13 portfolio companies

Solo GP fund backing European enterprise technology founders from pre-seed onward, with a focus on meaningful B2B software problems. The fund is known for a high-touch, founder-friendly model and earl...

• Enterprise
• SaaS
• AI / ML

• Pre-Seed, Seed
• $100K – $300K
• Berlin, Germany
• 5 portfolio companies

Systematic Ventures funds foundational tools for software teams, targeting emerging AI and DevOps innovations.

• Other
• Developer Tools

• Pre-Seed, Seed
• $300K – $2.0M
• New York, NY
• 2 portfolio companies

Enterprise-focused fund investing in software companies across legal tech, SaaS, cybersecurity, and workflow automation. The firm appears on legaltech investor lists with a broad enterprise compliance...

• Other
• Enterprise
• SaaS

• Pre-Seed, Seed, Series A
• $250K – $500K
• Arlington, VA
• 58 portfolio companies