Venture Capital Firms in the USA

Focused on transformative HealthTech and PharmaTech startups that utilize AI for operational efficiencies.

• Healthcare
• Other
• SaaS

• Pre-Seed, Seed
• $100K – $1.0M
• Boston, MA
• 5 portfolio companies

Focused on early-stage HealthTech and Pharmacy Tech startups revolutionizing pharmaceutical processes and services.

• Healthcare
• Other

• Pre-Seed, Seed
• $250K – $1.0M
• Raleigh, NC
• 1 portfolio company

Investing in next-generation hardware solutions for AI, semiconductor applications, and wireless technologies.

• Other
• AI / ML
• Developer Tools

• Seed, Series A
• $400K – $4.0M
• Cambridge, MA
• 26 portfolio companies

Backs early-stage companies in B2B SaaS with a focus on marketing, distribution, and data-driven strategies.

• SaaS
• Other

• Pre-Seed, Seed
• $1.0M – $5.0M
• San Francisco, CA
• 9 portfolio companies

Focus on early-stage B2B SaaS and marketplaces that solve specific niche pain points for enterprises.

• SaaS
• Marketplace
• Other

• Seed, Pre-Seed
• $250K – $3.0M
• Austin, TX
• 1 portfolio company

Investing in startups revolutionizing environmental due diligence workflows through AI-driven innovation.

• Other
• Real Estate
• AI / ML

• Pre-Seed, Seed
• $1.0M – $4.0M
• Boston, MA
• 1 portfolio company

PhaseShift Capital targets disruptive B2B AI software startups in underserved geographies. Their thesis emphasizes AI for lead generation, customer success, and automated workflows.

• AI / ML
• SaaS
• Enterprise

• Pre-Seed, Seed
• $200K – $1.0M
• Chicago, IL
• 10 portfolio companies

Invests in transformative life sciences technologies and companies addressing unmet medical needs.

• Healthcare
• Other

• Pre-Seed, Seed
• Austin, TX

Invests in early-stage companies harnessing photonic innovations for industrial and automotive applications.

• Other
• AI / ML
• Developer Tools

• Seed
• $750K – $2.5M
• Austin, TX
• 4 portfolio companies

Invests in early-stage companies innovating in AI and consumer software, with a preference for seamless integrations.

• AI / ML
• Consumer
• EdTech

• Pre-Seed
• $250K – $1.3M
• Boston, MA
• 9 portfolio companies

Investing in high-impact research tools, life sciences platforms, and SaaS software for scientists.

• Other
• SaaS

• Seed
• $75K – $500K
• Boston, MA
• 1 portfolio company

PhotonEdge Ventures specializes in photonics-based industrial and automotive technologies, with a focus on platforms that enable energy efficiency or replace legacy systems with precision photonic sol...

• Other

• Pre-Seed, Seed
• $250K – $2.0M
• Pasadena, CA
• 1 portfolio company

Dedicated to supporting pioneering companies in semiconductor and photonics innovations, with a focus on industrial applications.

• Other

• Seed
• $1.0M – $3.0M
• Austin, TX
• 3 portfolio companies

Dedicated to financing breakthroughs in photonics for defense and aerospace solutions, focusing on next-gen ignition systems.

• Other
• SaaS

• Seed, Pre-Seed
• $1.2M – $3.0M
• Boston, MA
• 19 portfolio companies

Sector-specific fund solely invested in photonic hardware solutions for industrial and consumer markets.

• Other

• Seed, Series A
• $250K – $2.0M
• Austin, TX
• 1 portfolio company

Invests exclusively in photonic technologies redefining industrial, medical, and automotive systems.

• Other

• Pre-Seed, Seed
• $500K – $3.0M
• Boston, MA
• 2 portfolio companies

Investing in physics-driven computational methods for diagnostics and drug discovery, uniquely bridging physical sciences and biotech.

• Other
• Healthcare

• Pre-Seed, Seed
• $250K – $1.5M
• Austin, TX
• 2 portfolio companies

Early-stage healthcare fund anchored by physicians focusing on technology and device solutions for healthcare workflows, excluding pharmaceuticals; prioritizes women’s health and underserved communiti...

• Other

• Pre-Seed, Seed, Series A
• $150K – $500K
• US

Piccolo Ventures invests in cutting-edge enterprise AI and automation startups that reduce the complexity in legacy systems and unlock scalable workflows.

• Other
• SaaS
• Enterprise

• Pre-Seed, Seed
• $1.0M – $4.0M
• Austin, TX
• 105 portfolio companies

Solo-GP fund focused exclusively on infrastructure/tools for crypto and fintech, especially ‘picks & shovels’ enabling builders rather than consumer apps or speculative tokens.

• Other
• Fintech
• Developer Tools

• Pre-Seed, Seed
• Up to $100K
• Santa Monica, California
• 14 portfolio companies

Pillar focuses on pre-seed and seed investments in breakthrough science, including enterprise intelligence, semiconductors, robotics, biotech, healthcare, manufacturing, and advanced computation.

• SaaS
• Enterprise
• Other

• Seed, Pre-Seed
• $50K – $7.0M
• Boston, Massachusetts, United States
• 7 portfolio companies

PilotHouse Ventures invests in SaaS and marketplace businesses disrupting traditional transaction behaviors.

• SaaS
• Marketplace

• Seed, Pre-Seed
• $500K – $3.0M
• Austin, TX
• 2 portfolio companies

Pine Ridge invests small checks in pre-seed teams building tools for upskilling, credentialing, and independent workforce career growth.

• Other
• EdTech

• Pre-Seed
• $50K – $300K
• Denver, Colorado
• 2 portfolio companies

Pinecone Capital focuses on early-stage investments in fintech-driven B2B SaaS platforms that enhance enterprise capabilities through cutting-edge data analytics.

• Fintech
• Developer Tools
• SaaS

• Pre-Seed, Seed
• $500K – $3.0M
• Austin, TX
• 2 portfolio companies