Venture Capital Firms in the USA

The OS Fund backs breakthrough ventures using deep tech and life sciences to solve humanity's biggest challenges.

• Healthcare
• AI / ML
• Deep Tech

• Seed, Pre-Seed
• $1.0M – $3.0M
• San Diego, CA
• 2 portfolio companies

Seed-stage digital health specialist focused on care delivery innovation and digital health infrastructure.

• Healthcare
• AI / ML
• EdTech

• Seed, Series A
• $250K – $1.5M
• Chicago, IL
• 35 portfolio companies

Invests in early-stage companies commercializing university-based or deep science innovations in biotech, medtech, and healthtech.

• Healthcare
• Other

• Seed, Pre-Seed, Series A
• $250K – $2.0M
• Bala Cynwyd, PA
• 2 portfolio companies

Investing in the cybersecurity and critical infrastructure innovation space, focusing on pre-seed startups tackling enterprise-level risks.

• Security
• Other

• Seed, Series A
• $500K – $2.5M
• New York, NY
• 2 portfolio companies

Invests in AI-powered infrastructure software enabling scalable enterprise workflows, with focus on industries undergoing digital transformation.

• Other
• SaaS

• Pre-Seed, Seed
• $250K – $2.5M
• San Francisco, CA
• 2 portfolio companies

Optum Ventures invests from seed through growth in companies at the intersection of healthcare and technology, including value-based care delivery, enterprise software and enabling infrastructure, and...

• Healthcare
• AI / ML

• Seed, Series A
• $1.5M – $5.0M
• Boston, Massachusetts, United States
• 1 portfolio company

Supports e-commerce innovations that revolutionize digital selling and multi-channel retail operations.

• Other
• Marketplace
• SaaS

• Seed
• $300K – $800K
• New York, NY
• 13 portfolio companies

Orbit Labs backs founders building productivity-focused B2B SaaS tools with AI/ML integration.

• SaaS
• Other
• Enterprise

• Pre-Seed, Seed
• $300K – $1.5M
• San Francisco, CA
• 39 portfolio companies

Focuses exclusively on early-stage companies innovating in aerospace and dual-use technologies.

• Other

• Pre-Seed
• $750K – $2.5M
• Los Angeles, CA
• 20 portfolio companies

Focuses on investing in early-stage aerospace and defense startups that harness cutting-edge technologies.

• Other
• Developer Tools
• SaaS

• Seed
• $1.0M – $3.0M
• Denver, CO
• 6 portfolio companies

Invests in startups advancing geospatial mapping and AI applications for urban infrastructure and global development.

• Other
• AI / ML

• Pre-Seed, Seed
• $250K – $3.0M
• San Francisco, CA
• 1 portfolio company

Orbx Ventures focuses on early-stage investments in B2B SaaS and AI startups, with an emphasis on companies building revenue-generation tools for marketing and sales teams.

• SaaS
• AI / ML
• Other

• Pre-Seed, Seed
• $250K – $1.0M
• Austin, TX
• 2 portfolio companies

Orca Ventures focuses exclusively on early-stage B2B SaaS companies solving industry-specific challenges.

• SaaS

• Seed
• $1.0M – $3.0M
• Austin, TX
• 2 portfolio companies

Invests in enterprise-grade AI-driven orchestration tools and platforms enabling faster, more efficient collaboration among developers and technical teams.

• Other
• SaaS
• Developer Tools

• Pre-Seed
• $300K – $1.5M
• New York, NY
• 2 portfolio companies

Focuses exclusively on addressing developer and engineering pain points by investing in tools that streamline workflows, increase productivity, and enable enterprise-wide adoption.

• Developer Tools
• Other
• AI / ML

• Pre-Seed, Seed
• $250K – $1.5M
• Portland, OR
• 5 portfolio companies

Focuses on scalable B2B SaaS solutions transforming restaurant operations and supporting independent operators with technological innovations.

• Other
• SaaS
• Food / AgTech

• Pre-Seed, Seed
• $500K – $3.0M
• Chicago, IL
• 2 portfolio companies

Invests in emerging startups tackling credit and lending innovation, especially for underserved demographics or founders.

• Fintech
• Other

• Pre-Seed, Seed
• $100K – $750K
• Atlanta, GA
• 2 portfolio companies

Focused on pre-seed and seed investments in enterprise-scale data and developer infrastructure for hybrid/multi-cloud ecosystems.

• Developer Tools
• Other
• SaaS

• Pre-Seed, Seed
• $250K – $2.0M
• Boston, MA
• 1 portfolio company

Focused on early-stage B2B SaaS and marketplace startups in underrepresented hubs including the Midwest.

• Marketplace
• SaaS

• Seed, Series A
• $500K – $4.0M
• Chicago, IL, USA
• 10 portfolio companies

Orion Blockchain Partners backs startups leveraging blockchain to improve transparency and compliance in financial services.

• Other
• Fintech

• Pre-Seed, Seed
• $200K – $500K
• San Francisco, CA

Targets companies with innovative solutions in orthotic devices and prosthetic technology.

• Other

• Seed, Series A
• $750K – $3.5M
• Seattle, WA
• 2 portfolio companies

Focuses on compliant DeFi protocols, blockchain infrastructure, and institutional finance applications.

• Other

• Seed, Series A
• $1.0M – $5.0M
• San Francisco, CA
• 1 portfolio company

Partners with university spinouts addressing transformative tech in biotech, healthcare, AI, and science-driven SaaS.

• Other
• Healthcare
• AI / ML

• Pre-Seed, Seed
• $750K – $3.0M
• Philadelphia, PA
• 137 portfolio companies

Focus on B2B SaaS companies with strong technical teams solving industry-specific problems.

• SaaS
• Enterprise

• Seed, Pre-Seed
• $250K – $1.0M
• Bala Cynwyd, PA
• 2 portfolio companies