Pre-Seed SaaS Venture Capital Firms

Focused on revolutionizing healthcare operations and enhancing patient engagement through B2B SaaS solutions.

• Healthcare
• Other
• SaaS

• Pre-Seed
• $500K – $2.0M
• London, UK
• 4 portfolio companies

Specializes in early-stage investments in companies revolutionizing healthcare operations and compliance.

• Healthcare
• Other
• SaaS

• Pre-Seed
• $500K – $2.5M
• Chicago, IL
• 1 portfolio company

Invests in early-stage companies developing software platforms to streamline B2B workflows in healthcare and pharmaceutical industries.

• Healthcare
• SaaS
• Enterprise

• Pre-Seed, Seed
• $75K – $300K
• Austin, TX
• 1 portfolio company

Invests in groundbreaking technological solutions in healthcare that improve patient care and operational efficiency.

• Healthcare
• SaaS
• AI / ML

• Pre-Seed
• $500K – $2.0M
• Boston, MA
• 2 portfolio companies

Focused on early-stage HealthTech and PharmaTech innovation with an emphasis on automation and robotics for healthcare efficiency.

• Healthcare
• Other
• SaaS

• Pre-Seed, Seed
• $250K – $1.5M
• Seattle, WA
• 2 portfolio companies

Micro VC specifically listed under healthtech. The name suggests a focused early-stage healthcare investing strategy, likely suited to very early B2B health software rounds.

• Healthcare
• SaaS
• Enterprise

• Pre-Seed, Seed
• $100K – $750K
• New York, New York
• 22 portfolio companies

Invests early in digital health startup pioneers improving the well-being of individuals and families.

• Healthcare
• Developer Tools
• Other

• Pre-Seed, Seed
• $300K – $2.0M
• San Francisco, CA
• 25 portfolio companies

Heartcore backs European technology founders at the early stage, from inception to Series A, with a stated focus on founders building outlier companies.

• Other
• SaaS
• AI / ML

• Pre-Seed, Seed
• $500K – $2.0M
• Copenhagen, Denmark
• 23 portfolio companies

Invests in innovative solutions in healthcare that leverage digital technology to improve healthcare outcomes.

• Healthcare
• SaaS
• AI / ML

• Pre-Seed, Seed, Series A
• $250K – $5.0M
• New York, NY
• 24 portfolio companies

Partnering with founders to build impactful B2B SaaS and HealthTech businesses across Europe.

• SaaS
• Marketplace
• Healthcare

• Seed, Pre-Seed
• $500K – $2.5M
• London, UK
• 1 portfolio company

Specializes in early-stage synthetic biology startups revolutionizing food systems, ingredients, and industrial applications.

• Healthcare
• Other
• Food / AgTech

• Pre-Seed, Seed
• $500K – $4.0M
• San Francisco, CA
• 2 portfolio companies

B2B SaaS-focused micro VC actively backing early-stage marketplace startups that streamline industry-specific workflows.

• SaaS
• Marketplace
• Consumer

• Pre-Seed, Seed
• $500K – $2.0M
• Austin, TX
• 2 portfolio companies

Focused exclusively on enabling early-stage, lean AI startups through targeted investments in SaaS-based enterprise solutions.

• Other
• Enterprise
• AI / ML

• Pre-Seed, Seed
• $250K – $1.0M
• Atlanta, GA
• 1 portfolio company

Hercules backs companies involved in public-private partnerships and financial innovations for government and enterprise.

• Other
• Fintech
• Enterprise

• Seed, Pre-Seed, Growth
• $1.0M – $5.0M
• Palo Alto, CA
• 31 portfolio companies

Investing in platforms that trace and enhance cultural roots through digital experiences.

• EdTech
• Marketplace
• Other

• Pre-Seed, Seed
• $250K – $1.5M
• San Francisco, CA
• 1 portfolio company

Seed-focused emerging manager from Israel investing in deep technical enterprise software, including cybersecurity and cloud infrastructure.

• Security
• Developer Tools
• Other

• Pre-Seed, Seed
• $500K – $1.5M
• Tel Aviv, Israel
• 17 portfolio companies

Invests in cutting-edge SaaS solutions for private markets, emphasizing automation and AI technology integration.

• AI / ML
• Other
• SaaS

• Pre-Seed
• $100K – $500K
• San Francisco, CA
• 24 portfolio companies

Focused on early-stage AI and SaaS startups that enhance productivity and workflows for businesses.

• Other
• SaaS
• Enterprise

• Pre-Seed, Seed
• $250K – $2.0M
• Austin, TX
• 1 portfolio company

High Voltage Capital invests in early-stage startups in Europe and North America working on clean energy, grid technology, and fusion systems.

• Climate / Energy
• Other
• SaaS

• Seed, Pre-Seed
• $300K – $3.0M
• Berlin, Germany
• 2 portfolio companies

Focused on creating and launching enterprise software companies from scratch, particularly in the B2B SaaS space.

• SaaS
• Enterprise

• Pre-Seed, Seed
• $250K – $1.0M
• Indianapolis, IN
• 92 portfolio companies

Backs early-stage businesses creating tools to improve operational efficiency through AI-driven insights.

• SaaS
• Enterprise
• Other

• Pre-Seed, Seed
• $150K – $2.0M
• Austin, TX
• 2 portfolio companies

Focused on tech innovations in sports, entertainment, and fan engagement spaces that enable data-driven and emotional connection opportunities.

• Other
• SaaS

• Pre-Seed, Seed
• $100K – $2.5M
• Denver, CO
• 5 portfolio companies

Focused on platforms simplifying transactions for small businesses, builders, and underserved real estate developers.

• Marketplace
• Real Estate
• SaaS

• Pre-Seed, Seed
• $300K – $2.5M
• Denver, CO
• 2 portfolio companies

Highline Beta specializes in working with early-stage companies reinventing B2B and financial systems.

• Fintech
• SaaS
• Other

• Pre-Seed, Seed
• $200K – $750K
• Toronto, Canada (US portfolio presence)
• 2 portfolio companies